Joshi Lab
Tumor Microenvironment and Myeloid Cell Biology: Paving the Way for New Therapies
About the Lab
Our lab is dedicated to understanding the complex biology of the tumor microenvironment (TME) and its influence on cancer progression. We focus on the role of myeloid cells, such as macrophages and myeloid-derived suppressor cells (MDSCs), in shaping the TME. These cells can either support tumor growth by promoting an immunosuppressive environment or be reprogrammed to enhance anti-tumor immunity. By studying the mechanisms that regulate myeloid cell function within the TME, we aim to identify new strategies for cancer therapy. Our research leverages advanced technologies, including spatial transcriptomics, immune phenotyping, system biology approaches, and preclinical models, along with human patient samples, to explore potential ways to manipulate the TME and myeloid cells for more effective cancer treatments.
Meet the PI
Shweta Joshi, PhD is currently an Assistant Professor at UC San Diego Moores Cancer Center. Dr. Joshi received her Ph.D. in Biochemistry from Central Drug Research Institute, India. Following the completion of her Ph.D., Dr. Joshi joined postdoc at the University of California, San Diego. During the postdoctoral fellowship, her research was focused on finding novel signaling pathways in macrophages that mediate tumor growth and immunosuppression. In 2019, Dr. Joshi joined as an Assistant Professor in the Department of Pediatrics, UCSD.