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The Division of Genome Information Sciences was established in the fall of 2009 and is led by Dr. Kelly Frazer in the UC San Diego School of Medicine's Department of Pediatrics. The faculty in the division work closely with physicians in the Department of Pediatrics   and Rady Children's Hospital, and collaborates frequently with the university's Institute for Genomic Medicine.  

The main function of this division is to use genomic information as a basis for focusing on the predisposition for complex diseases and cancer starting in childhood but spanning the whole age spectrum. Research aims to understand genetic predisposition to disease or individual responses to treatment, such as the ability to tolerate or safely metabolize drugs.