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Selected Publications

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Caldera JR, Tsai CM, Trieu D, Gonzalez C, Hajam IA, Du X, Lin B, Liu GY. The characteristics of pre-existing humoral imprint determine efficacy of S. aureus vaccines and support alternative vaccine approaches. Cell Rep Med. 2024 5:101360. PMID: 38232694.

Hajam IA, Katiki M, McNally R, Lázaro-Díez M, Kolar S, Chatterjee A, Gonzalez C, Paulchakrabarti M, Choudhury B, Caldera JR, Desmond T, Tsai CM, Du X, Li H, Murali R, Liu GY. Functional divergence of a bacterial enzyme promotes healthy or acneic skin. Nat Commun. 2023 Dec 05; 14(1):8061. PMID: 38052825.

Tsai CM, Hajam IA, Caldera JR, Liu GY. Integrating complex host-pathogen immune environments into S. aureus vaccine studies. Cell Chem Biol. 2022 05 19; 29(5):730-740.  PMID: 35594849.

Tsai CM, Caldera JR, Hajam IA, Chiang AWT, Tsai CH, Li H, Díez ML, Gonzalez C, Trieu D, Martins GA, Underhill DM, Arditi M, Lewis NE, Liu GY. Non-protective immune imprint underlies failure of Staphylococcus aureus IsdB vaccine. Cell Host Microbe. 2022 08 10; 30(8):1163-1172

The publication above was featured in "A Staph Vaccine Trial Failure Shows Challenges of Stopping Common Bugs." 

Kolar SL, Tsai CM, Torres J, Fan X, Li H, Liu GY. Propionibacterium acnes-induced immunopathology correlates with health and disease association. JCI Insight. 2019 Mar 07; 4(5). PMID: 30843879.

Das MM, Godoy M, Chen S, Moser VA, Avalos P, Roxas KM, Dang I, Yáñez A, Zhang W, Bresee C, Arditi M, Liu GY, Svendsen CN, Goodridge HS. Young bone marrow transplantation preserves learning and memory in old mice. Commun Biol. 2019; 2:73. PMID: 30820468.

Khan Z, Cao DY, Giani JF, Bernstein EA, Veiras LC, Fuchs S, Wang Y, Peng Z, Kalkum M, Liu GY, Bernstein KE. Overexpression of the C-domain of angiotensin-converting enzyme reduces melanoma growth by stimulating M1 macrophage polarization. J Biol Chem. 2019 Jan 22. PMID: 30670595.

Mikheyeva IV, Thomas JM, Kolar SL, Corvaglia AR, Ga?a N, Leo S, Francois P, Liu GY, Rawat M, Cheung AL. YpdA, a putative bacillithiol disulfide reductase, contributes to cellular redox homeostasis and virulence in Staphylococcus aureus. Mol Microbiol. 2019 Jan 12. PMID: 30636083.

Thomsen IP, Liu GY. Targeting fundamental pathways to disrupt Staphylococcus aureus survival: clinical implications of recent discoveries. JCI Insight. 2018 Mar 08; 3(5). PMID: 29515041.

Sanchez M, Kolar SL, Müller S, Reyes CN, Wolf AJ, Ogawa C, Singhania R, De Carvalho DD, Arditi M, Underhill DM, Martins GA*, Liu GY*. O-Acetylation of Peptidoglycan Limits Helper T Cell Priming and Permits Staphylococcus aureus Reinfection. Cell Host Microbe. 2017 Oct 11; 22(4):543-551.e4. PMID: 28943328.

Khan Z, Shen XZ, Bernstein EA, Giani JF, Eriguchi M, Zhao TV, Gonzalez-Villalobos RA, Fuchs S, Liu GY, Bernstein KE. Angiotensin-converting enzyme enhances the oxidative response and bactericidal activity of neutrophils. Blood. 2017 07 20; 130(3):328-339. PMID: 28515091.

Tseng CW, Biancotti JC, Berg BL, Gate D, Kolar SL, Muller S, Rodriguez MD, Rezai-Zadeh K, Fan X, Beenhouwer DO, Town T, Liu GY. Increased susceptibility of humanized NSG mice to Panton-Valentine leukocidin and Staphylococcus aureus skin infection. PLOS Pathog. 2015;11(11):e1005292. 

Sabrina Müller, Wolf AJ, Iliev ID, Berg BL, Underhill DM*, Liu GY*. Poorly cross-linked peptidoglycan in MRSA due to mecA induction activates the inflammasome and exacerbates immunopathology. Cell Host Microbe. 2015;18(5):604-612. 

Tseng CW, Liu GY. Expanding roles of neutrophils in aging hosts. Curr Opin Immunol. 2014 Aug;29:43-48. 

Kyme P, Thoennissen NH, Tseng CW, Iwanski GB, Shimada K, Krug UO, Lee K, Hardy WD, Gombart AF, Koeffler HP*, Liu GY*. C/EBPε mediates nicotinamide-enhanced clearance of Staphylococcus aureus in mice. J Clin Invest. 2012;122(9):3316-3329.

 Kolar SL, Liu GY. RAS and ROS - A Story of Pseudomonas Survival. Cell Host Microbe. 2017 May 10; 21(5):551-552. PMID: 28494232.

Wolf AJ, Liu GY, Underhill DM. Inflammatory properties of antibiotic-treated bacteria. J Leukoc Biol. 2017 01; 101(1):127-134. PMID: 27576461.

Kolar S, Kyme P, Tseng CW, Soliman A, Kaplan A, Liang J, Nizet V, Jiang D, Murali R, Arditi M, Underhill DM, Liu GY. Group B Streptococcus evades host immunity by degrading hyaluronan.  Cell Host Microbe. 2015;18(6):694-704. 

Park B, Liu GY. Targeting the host-pathogen interface for treatment of Staphylococcus aureus infection. Sem Immunopath. 2012;34(2):299- 

Shimada T, Park B, Goodridge HS, Wolf AJ, Becker CA, Reyes CN, Miao EA, Aderem A, Götz F, Liu GY, Underhill DM. Staphylococcus aureus evades lysozyme-based peptidoglycan digestion that links phagocytosis, inflammasome activation and IL-1beta secretion. Cell Host Microbe. 2010;7(1):38-49. 

Tseng CW, Kyme P, Low J, Rocha MA, Alsabeh R, Miller LG, Otto M, Arditi M, Diep BA, Nizet V, Doherty TM, Beenhouwer DO, Liu GY. Staphylococcus aureus Panton-Valentine leukocidin contributes to inflammation and muscle tissue injury. PLOS ONE. 2009;4(7):e6837. 

Liu GY, Nizet V. Color me bad: microbial pigments as virulence factors. Trends Microbiol. 2009;17(9):406-413. 

Liu C-I*, Liu GY*, Song Y*, Yin F, Hensler ME, Nizet V, Wang AH, Oldfield E. A cholesterol biosynthesis inhibitor blocks Staphylococcus aureus virulence. Science. 2008;319(5868):1391-1394.

Park B, Nizet V, Liu GY. Role of Staphylococcus aureus catalase in niche competition against Streptococcus pneumoniae. J Bacteriol. 2008;190(7):2275-2278. 

Liu GY, Essex A, Buchanan JT, Datta V, Fierer J, Nizet V. Staphylococcus aureus golden pigment impairs neutrophil killing and promotes virulence through its antioxidant activity. J Exp Med. 2005;202(2):209-215. 

Liu GY, Doran K, Lawrence T, Turkson N, Puliti M, Tissi L, Nizet V. Sword and shield: linked group B streptococcal β-hemolysin/cytolysin and carotenoid pigment function to subvert host phagocyte defense. Proc Natl Acad Sci USA. 2004;101(40):14491-14496. 

Doran K., Liu GY, Nizet V. Group B streptococcal β-hemolysin/cytolysin activates neutrophil signaling pathways in brain endothelium and contributes to development of meningitis. J Clin Invest. 2003;112(5):736-744. 

Liu, GY, Fairchild, PJ, Smith, RM, Prowle, JR, Koussis, D, Wraith, DC. Low avidity recognition of self-antigen by T cells permits escape from central tolerance. Immunity. 1995;3(4):407-415.