Currently my work at the Rady Children’s Institute for Genomic Medicine (RCIGM) focuses on helping to create the clinical evidence which will allow all children to have access to the benefits of clinical advances in next generation sequencing. With the group at the RCIGM we are using rapid whole genome sequencing to aid in the care of critically ill infants. We use both whole genome sequencing, transcriptomics and pathogen sequencing to better define the disease process in the critically ill child. We are expanding our clinical work and actively developing clinical trials to test various uses for this technology. By creating evidence for the application of rapid sequencing techniques we are working to change the standard of care for children. Our work is largely clinical/implementation science with a focus on practical application including clinical utility and health economics.