Muotri Lab

Current research projects deal with examining the development of brain tissue in stem cell-derived "brain organoids."

1. To understand the fundamental basis of the organization of the social brain, Dr. Muotri is observing the advantages of the human condition in situations where the social aspect is compromised. Using human pluripotent stem cells to recreate the neural developmental stages of autism and other social disorders, Dr. Muotri is modeling diseases in a dish. This allows him to investigate the mechanisms responsible for alterations in neuronal networks. By testing the responses of this tissue to drugs within a dish, he is looking to revert the defects seen in diseased states. If a drug increases the number of synaptic connections in autism, for example, it can be deemed effective and move more quickly into clinical trials. This is opening novel therapeutic avenues while accelerating the translational response to this research.
2. Dr. Muotri is also interested in studying the social brain from an unconventional, evolutionary perspective. Much of the genetic information on Neanderthals is based on the fossil record and DNA samples extracted from remains. When this genetic information is compared to the genome of humans, there are changes present that are not seen in modern humans. Using cutting-edge genome-editing technologies, Dr. Muotri is re-creating genetic variants that were negatively selected in extinct humans, such as the Neanderthals, in neurons derived from stem cells. He is looking at what properties were likely responsible for limiting the Neanderthal's social, cultural, and technological development and contributed to their extinction. By doing so, Dr. Muotri's lab may generate innovative hypotheses about the human social brain with direct impact on human mental health. This has never been dreamed possible in the past.
3. We have all the genes represented within the human genome, yet they are contained in only 1% of all human DNA. For this reason science has dealt considerably with this 1%, with the other 99% remaining relatively unknown, naively referred to as "junk" DNA in the past. However, Dr. Muotri has identified discrete genetic elements in our genome that can move from one place to another, affecting the behavior of individual cells. This is evidence to believe these “jumping genes” are responsible for the individuality of each human brain, while also potentially being implicated in several neuro- and psychiatric disorders. This may help to explain why we are all different in thought and behavior, even when raised in the same environment.