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Alexandra Stream

MSTP student

Research Interests

  • Group A Streptococcal Infection
  • Immunity/Autoimmunity
  • Vaccines

At the Bench

Alex Stream is an MD/PhD student in the Medical Scientist Training Program (MSTP) at UCSD. She earned her B.S. in Microbiology, Immunology, and Molecular Genetics from UCLA, where she conducted parasitology research and developed what has become a longstanding interest in infectious diseases. After graduating, Alex conducted research on oncogenic viruses at the NIH in Bethesda, Maryland, for two years through the Postbac Intramural Research Training Award Program. She returned to the west coast in 2019 to begin the MSTP. Currently, she studies autoimmunity, vaccine immunology, and immune correlates of protection related to Group A Streptococcus and rheumatic heart disease in the Nizet lab.

Outside of Lab 

In her free time, Alex can often be found tossing a frisbee at the beach, paddleboarding, and catching as many musicals as she can. She also enjoys singing in choir and in a cappella groups.

 

Education

University Degree Year Field
University of California San Diego, La Jolla, CA MD/PhD In progress Microbiology and Immunology
University of California Los Angelos, Los Angelos CA B.S. 2017 Microbiology, Immunology, and Molecular Genetics

Honors

Year Honor/Award
2023-2024 BioLegend Graduate Fellowship in Immunology, UCSD
2024 Advancing EDI Group Award, UC San Diego School of Biological Sciences
2016 Whitcome Summer Undergraduate Research Fellowship, UCLA
2016 – 2017 Undergraduate Research Scholars Program: Smith Endowment Award, UCLA

Publications

Bjånes E#, Stream A#, Janssen AB, Gibson PS, Bravo AM, Dahesh S, Baker JL, Varble A, Nizet V, Veening J-W. An efficient in vivo-inducible CRISPR interference system for group A Streptococcus genetic analysis and pathogenesis studies. mBio. 2024 Jul 2;:e0084024. doi: 10.1128/mbio.00840-24. PubMed PMID: 38953375.

Stream A, Corriden R, Döhrmann S, Gallo RL, Nizet V, Anderson EL. The Effect of Retinoic Acid on Neutrophil Innate Immune Interactions With Cutaneous Bacterial Pathogens. Infect Microbes Dis. 2024 Jun;6(2):65-73. doi: 10.1097/im9.0000000000000145. Epub 2024 Apr 29. PubMed PMID: 38952747.

Kim J, Uchiyama S, Gong , Stream A, Zhang L, Nizet V. Engineered Biomimetic Platelet Membrane-Coated Nanoparticles Block Staphylococcus aureus Cytotoxicity and Protect Against Lethal Systemic Infection. Engineering. 2020 December; 7(8):1149-1156. doi: https://doi.org/10.1016/j.eng.2020.09.013.

Stream A, Madigan CA. Zebrafish: an underutilized tool for discovery in host-microbe interactions. Trends Immunol. 2022 Jun;43(6):426-437. doi: 10.1016/j.it.2022.03.011. Epub 2022 May 5. Review. PubMed PMID: 35527182.