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  6. Anh T. P. Ngo

Anh T. P. Ngo

Postdoctoral Fellow

Research Interests

  • Host-Pathogen Interactions
  • Vascular Biology
  • Thrombosis & Hemostasis

At the Bench

Anh received her graduate training in Biomedical Engineering under the mentorship of Dr. Owen McCarty at Oregon Health & Science University in 2021. Her thesis work focused on platelet signaling and platelet-coagulation crosstalk in hemostasis and inflammatory diseases. She then pursued her postdoctoral fellowship in the laboratory of Dr. Kandace Gollomp in the Division of Hematology at the Children’s Hospital of Philadelphia, where she studied the interplay between platelets, neutrophils, and endothelial cells in modulating pathogen clearance to improve sepsis outcomes. Anh joined the Nizet laboratory in the spring of 2024 to study mechanism of platelets in combating drug-resistant pathogens, and explore novel therapeutic strategies for the treatment of sepsis and other thromboinflammatory disorders.

Outside of Lab

Anh enjoys pilates, hiking, biking, and backpacking. In her free time, she hangs out with her husband and puppy, tries out new coffee shops and bookstores, and video calls her family and friends to catch up.

Education

University Degree Year Field
University of California San Diego, La Jolla CA Postdoc 2024-present Host-Microbe Systems & Therapeutics
The Children's Hospital of Pennsylvania, Philadelphia PA Postdoc 2021-2024 Hematology
Oregon Health & Science University, Portland OR Ph.D. 2021 Biomedical Engineering
Warner Pacific University, Portland OR B.S. 2015 Biological Sciences & Chemistry

 

Honors

Year Honor
2022-2024 Brody Family Medical Trust Fund Fellowship in Incurable Diseases
2023 Top Scoring Abstract Award, Philadelphia Workshop on Hemostasis, Thrombosis and Atherosclerosis
2023 Early Career Award, International Society on Thrombosis and Haemostasis
2022 Brody Family Medical Trust Fund Fellowship in Incurable Diseases, The Philadelphia Foundation
2022 Thrombosis & Hemostasis Summit of North America Young Investigator Award
2022 International Society on Thrombosis and Haemostasis (ISTH) Early Career Award
2021 Invited speaker, Oregon Health & Science University School of Medicine Graduation
2021 American Society of Hematology Abstract Achievement Award
2021 ISTH Early Career Award
2018 Oregon Health & Science University N. L. Tartar Trust Fellowship
2018 ISTH Young Investigator Award
2017 Biomedical Engineering Society Career Development Award
2016 Sigma Xi Graduate Student Research Award in Cell Biology and Biochemistry
2015 Sigma Xi Undergraduate Biomedical Science Outstanding Research Poster
2015 Warner Pacific University Outstanding Achievement in Science and Mathematics Award
2011-2015 Warner Pacific University Dean’s List
2011-2015 Warner Pacific University Trustee’s Scholarship
2012 Warner Pacific University Freshman Achievement Award

Publications

Ngo AT, Bochenek V, Gollomp K. The immunology of PF4-polyanion interactions. Current Opinion in Hematology 2023; 30(6):219-229. PMID: 37603711

Mao Y, Tan M, Sylman JL, Puy C, Ngo AT, McCarty OJT, Walker TW. Transient particle tracking microrheology of plasma coagulation via the intrinsic pathway. Applied Rheology 2023; 33:20220129.

Ngo AT, Skidmore A, Oberg J, Yarovoi I, Sarkar A, Levine ND, Bochenek V, Zhao G, Rauova L, Kowalska MA, Eckart K, Mangalmurti NS, Rux A, Cines DB, Poncz M, Gollomp K. Platelet factor 4 limits neutrophil extracellular trap- and cell-free DNA-induced thrombogenicity and endothelial injury. JCI Insight 2023; 8(22):e171054. PMID: 37991024.

Ngo AT, Gollomp K. Building a better NET: Neutrophil extracellular trap targeted therapeutics in the treatment of infectious and inflammatory disorders. Research and Practice in Thrombosis and Haemostasis 2022; 6(7):e12808.

Kim HJ, Rames M, Tassi Yunga S, Armstrong R, Morita M, Ngo AT, McCarty OJT, Civitci F, Morgan TK, Ngo TTM. Irreversible alteration of extracellular vesicle and cell-free messenger RNA profiles in human plasma associated with blood processing and storage. Scientific Reports 2022; 12:2099. PMID: 35136102.

Ngo AT, Parra-Izquierdo I, Aslan JE, McCarty OJT. Rho GTPase regulation of reactive oxygen species generation and signaling in platelet function and disease. Small GTPases 2021; 1-18. PMID: 33459160.

Zheng TJ, Lofurno ER, Melrose AR, Lakshmanan H, Pang J, Phillips KG, Fallon ME, Kohs T, Ngo AT, Shatzel JJ, Hinds MT, McCarty OJT, Aslan JE. Assessment of the effects of Syk and BTK inhibitors on GPVI-mediated platelet signaling and function. American Journal of Physiology: Cell Physiology 2021; 320 (5):C902-C915. PMID: 33689480

Ngo AT, Jordan KR, Mueller PA, Puy C, Reitsma SE, Hagen MW, Revenko AS, Lorentz CU, Tucker EI, Hinds MT, Fazio S, Monia BP, Gailani D, Gruber A, Tavori H, McCarty OJT. Pharmacological targeting of coagulation Factor XI mitigates the development of experimental atherosclerosis in low-density lipoprotein receptor-deficient mice. Journal of Thrombosis and Haemostasis 2021; 19(4):1001-1017. PMID: 33421301.

Ngo AT, Jongen S, Shatzel JJ, McCarty OJT. Platelet integrin activation surfs the calcium waves. Platelets 2020; 1-3. PMID: 32441552.

Ngo AT, Sheriff J, Rocheleau AD, Bucher M, Jones KR, Sepp AI, Malone LE, Zigomalas A, Maloyan A, Bahou WF, Bluestein D, McCarty OJ, Haley KM. Assessment of neonatal, cord, and adult platelet granule trafficking and secretion. Platelets 2020; 31(1):67-68. PMID: 30810440.

Lakshmanan H, Melrose AR, Sepp A-L, Mitrugno A, Ngo AT, Khader A, Thompson R, Sallee D, Pang J, Mangin PH, Jandrot-Perrus M, Aslan JE, McCarty OJT. The basement membrane protein nidogen-1 supports platelet adhesion and activation. Platelets 2020; 1-5. PMID: 32233694.

Ngo AT, Aslan JE, McCarty OJ. Bleeding TAPs out. Journal of Thrombosis and Haemostasis 2019; 17(2):247-249. PMID: 30549218.

Rigg RA, Healy LD, Chu TT, Ngo AT, Mitrugno A, Zilberman-Rudenko J, Aslan JE, Hinds MT, Vecchiarelli LD, Morgan TK, Gruber A, Temple KJ, Lindsley CW, Duvernay MT, Hamm HE, McCarty OJ. Protease-activated receptor 4 (PAR4) activity promotes platelet granule release and platelet-leukocyte interactions. Platelets 2019; 30(1):126-135. PMID: 30560697.

Rocheleau AD, Melrose AR, Cunliffe JM, Klimek J, Babur O, Tassi Yunga S, Ngo AT, Pang J, David J, McCarty OJ, Aslan JE. Identification, quantification and systems analysis of cytosolic protein N-ϵ lysine methylation in anucleate blood platelets. Proteomics 2019; 19(11):e1900001. PMID: 30977292.

Puy C, Ngo AT, Pang J, Keshari RS, Hagen MW, Hinds MT, Gailani D, Gruber A, Lupu F, McCarty OJ. Endothelial plasminogen activator inhibitor-1 blocks the intrinsic pathway of coagulation, inducing the clearance and degradation of factor XIa. Arterioscler Thromb & Vasc Biol 2019; 39(7): 1390-1401. PMID: 31242030.

Shirai T, Revenko AS, Tibbits J, Ngo AT, Mitrugno A, Healy LD, Johnson J, Tucker EI, Hinds MT, Coussens LM, McCarty OJ, Monia BP, Gruber A. Hepatic thrombopoietin gene silencing reduces platelet count and breast cancer progression in transgenic MMTV-PyMT mice. Blood Advances 2019; 3(20):3080-3091. PMID: 31648335.

Babur O,* Ngo AT,* Rigg RA, Pang J, Rub ZT, Buchanan AE, Mitrugno A, LL David, McCarty OJ, Demir E, Aslan JE. Platelet procoagulant phenotype is modulated by a p38 - MK2 axis regulating RTN4/Nogo proximal to the endoplasmic reticulum: utility of pathway analysis. American Journal of Physiology: Cell Physiology 2018; 314(5):C603-C615.*equally contributing first authors PMID: 29412690.

Ngo AT, McCarty OJ, Aslan JE. TRPing out platelet calcium – TRPM7 modulates calcium mobilization and platelet function via PLC interactions. Arterioscler Thromb & Vasc Biol 2018; 38(2):285-286. PMID: 29367228.

Rocheleau AD, Khader A, Ngo AT, Boehnlein C, McDavitt C, Lattimore S, Recht M, McCarty OJ, Haley KM. Pilot study of novel lab methodology and testing of platelet function in adolescent women with heavy menstrual bleeding. Pediatric Research 2018; 83(3):693-701. PMID: 29166373.

Mitrugno A, Rigg RA, Laschober NB, Ngo AT, Pang J, Williams CD, Aslan JE, McCarty OJ. Potentiation of TRAP-6-induced platelet dense granule release by blockade of P2Y12 signaling with MRS2395. Platelets 2018; 29(4):383-394. PMID: 28523947.

Ngo AT, Thierheimer ML, Pang J, Babur O, Rocheleau AD, Rigg RA, Mitrugno A, Huang T, Nan X, Burchard J, Demir E, McCarty OJT,* Aslan JE.* Assessment of roles for the Rho-specific guanine nucleotide dissociation inhibitor (RhoGDI) Ly-GDI in platelet function. American Journal of Physiology: Cell Physiology 2017; 312(4):C527-C536. *co-senior authors PMID: 28148498.

Mitrugno A, Sylman JL, Ngo AT, Pang J, Sears RC, Williams CD, McCarty OJ. Aspirin therapy reduces the ability of platelets to promote colon and pancreatic cancer cell proliferation: implications for the oncoprotein c-MYC. American Journal of Physiology: Cell Physiology 2017; 312(2):C176-C189.: 27903583.