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About the Nizet Lab

The Nizet lab has published over 500 articles contributing to groundbreaking research in innate immunity, host-pathogen interactions, bacterial pathogenesis, translational medicine, and novel antimicrobial therapeutics. The lab has fostered the growth and scientific development of over 200 students, fellows, and postdocs during their training. Nizet trainees have gone on to establish independent research programs at renowned academic institutions, develop novel therapies at biotech companies, advance human health at the bedside, and persue many other pathways.

 

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Victor Nizet, M.D.

Distinguished Professor, Vice Chair for Basic Research, Department of Pediatrics
Chief, Division of Host-Microbe Systems & Therapeutics
Distinguished Professor, School of Pharmacy and Pharmaceutical Sciences
vnizet@ucsd.edu 
Publications 

 

Our Research Focus

The interest of the Nizet laboratory lies in understanding fundamental mechanisms of bacterial pathogenesis and the innate immune system, with a special focus on human streptococcal and staphylococcal infections. Using a molecular genetic approach, the laboratory seeks to discover and characterize bacterial virulence determinants involved in cytotoxicity, adherence, invasion, inflammation, molecular mimicry and resistance to immunologic clearance.

Bacterial Pathogenesis

Using a molecular genetic approach, the lab seeks to discover and characterize bacterial virulence determinants involved in cytotoxicity, adherence, invasion, molecular mimicry and resistance to immunologic clearance.

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Innate Immunity

In companion studies, we investigate the contribution of host factors such as antimicrobial peptides, leukocyte surface receptors, signal transduction pathways, and transcription factors in defense against invasive bacterial infection.

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Therapeutics & Vaccines

Ultimately, we believe the nexus of host-pathogen interactions will elucidate novel treatment strategies including biotherapeutics, antibiotic repurposing, and vaccines to augment host innate immune function in the context of infection.

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