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Publications

Mohanty T, Karlsson CAQ, Chao Y, Malmström E, Bratanis E, Grentzmann A, Mørch M, Nizet V, Malmström L, Linder A, Shannon O, Malmström J. A pharmacoproteomic landscape of organotypic intervention responses in Gram-negative sepsis. Nat Commun 2023;14:3603  ABSTRACT  |  PDF
Hirose Y, Poudel S, Sastry A, Rychel K, Zielinski D, Lim H, Menon N, Bergsten H, Uchiyama SA, Hanada T, Kawabata S, Palsson BO,  Nizet V. Elucidation of independently modulated genes in Streptococcus pyogenes reveals carbon sources that control its expression of hemolytic toxins. mSystems 2023 Jun 6;e0024723.  ABSTRACT  |  PDF
Baglaenko Y, Wagner C, Bhoj V, Brodin P, Gershwin E, Graham D, Invernizzi P, Kidd K, Kuronsky I, Levy M, Mammen A, Nizet V, Ramirez-Valle F, Sites E, Williams M, Wilson M, Rose N, Ladd V, Sirota M. Making inroads to precision medicine for the treatment of autoimmune diseases: harnessing genomic studies to better diagnose and treat complex disorders. Cambridge Prisms: Precis Med 2023; 1:e25.  ABSTRACT | PDF
Mu A, Klare WP, Baines SL, (multiple authors), Cole JN, Nizet V, (multiple authors), Stinear TP, Schembri MA, Walker MJ. Integrative omics identifies conserved and pathogen-specific responses of sepsis-causing bacteria. Nat Commun 2023;14:1530. ABSTRACT | PDF
Catteau L, Iglesias YD, Tsunemoto H, Pogliano J, Van Bambeke F, Nizet V, Sakoulas G. Nafcillin augmentation of daptomycin and cathelicidin LL-37 killing of methicillin-resistant Staphylococcus epidermidis: foundations of successful therapy of endocarditis. Int J Antimicrob Agents 2023; 61:106758. ABSTRACT | PDF
Anderson E, Nair B, Nizet V, Kumar G. Man vs microbes - the race of the century. J Med Microbiol 2023; 72(1). ABSTRACT | PDF
Osowicki J, Nizet V. Malice in Chains. J Infect Dis. 2023 Feb 7:jiad035. PDF
Pashangeh S, Berizi E, Majlesi M, Ghaderi S, Nizet V, Dahesh S. Effect of eliminating hdcA gene of Staphylococcus epidermidis TYH1 on histamine production. Iran J Microbiol 2022;14:529-534. ABSTRACT | PDF
Barajas-Mora EM, Lee L, Lu H, Valderrama JA, Bjanes E, Nizet V, Feeney AJ, Hu M, Murre C. Enhancer-instructed epigenetic landscape and chromatin compartmentalization dictate a primary antibody repertoire protective against specific bacterial pathogens. Nat Immunol 2023;24:320-336. ABSTRACT  | PDF
CRMS.jpg Kumaraswamy M, Coady A, Szubin R, Martin TC, Palsson B, Nizet V, Monk JM. Comprehensive whole genome sequencing with hybrid assembly of multi-drug resistant Candida albicans isolate causing cerebral abscess. Curr Res Microb Sci 2023;4:100180. ABSTRACT  |  PDF
AdvNanoBioMed.png Bjanes E, Zhou J, Qayum T, Zurich RH, Menon ND, Hoffman A, Fang RH, Zhang L, Nizet V. Outer membrane vesicle-coated nanoparticle vaccine protects against Acinetobacter baumannii pneumonia and sepsis. Adv Nanobiomed Res 2023; 3:2200130. ABSTRACT  |  PDF
Poudel S, Hefner Y, Szubin R, Sastry A, Gao Y, Nizet V, Palsson BO. Coordination of CcpA and CodY regulators in Staphylococcus aureus USA300 strains. mSystems. 2022 Nov 2:e0048022. Epub ahead of print.  ABSTRACT  |  PDF
Masso-Silva JA, Sakoulas G, Olay J, Groysberg V, Geriak M, Nizet V, Crotty Alexander LE, Meier A. Abrogation of neutrophil inflammatory pathways and potential reduction of neutrophil-related factors in COVID-19 by intravenous immunoglobulin. Front Immunol. 2022;13:993720.  ABSTRACT  |  PDF
Thomas SP, Denizer E, Zuffa S, Best BM, Bode L, Chambers CD, Dorrestein PC, Liu GY, Momper JD, Nizet V, Tsunoda SM, Tremoulet AH. Transfer of antibiotics and their metabolites in human milk: Implications for infant health and microbiota. Pharmacotherapy 2022 (epub ahead of print)  ABSTRACT  |  PDF
Zhang F, Zhuang J, Li Z, Gong H, de Ávila BE, Duan Y, Zhang Q, Zhou J, Yin L, Karshalev E, Gao W, Nizet V, Fang RH, Zhang L, Wang J. Nanoparticle-modified microrobots for in vivo antibiotic delivery to treat acute bacterial pneumonia. Nat Mater 2022; 21:1324-1332.   ABSTRACT  |  PDF  |  Press Release
Siew R, Ou TL, Dahesh S, Akong K, Nizet V. Bicarbonate effects on antibacterial immunity and mucus glycobiology in the cystic fibrosis lung: a review with selected experimental observations. Infect Microb Dis 2022; 4:103-110. ABSTRACT  | PDF
Sorrentino JT, Golden GJ, Morris C, Painter CD, Nizet V, Campos AR, Smith JW, Karlsson C, Malmström J, Lewis NE, Esko JD, Gómez Toledo A. Vascular proteome responses precede organ dysfunction in a murine model of Staphylococcus aureus bacteremia. mSystems. 2022; 7:e0039522.  ABSTRACT  |  PDF 
Bergmann R, Gulotta G, Andreoni F, Sumitomo T, Kawabata S, Zinkernagel AS Chhatwal GS, Nizet V, Rohde M, Uchiyama S. The group A Streptococcus interleukin-8 protease SpyCEP promotes bacterial intracellular survival by evasion of autophagy. Infect Microb Dis 2022; 4:116-123.  ABSTRACT   |  PDF
Kapoor N, Uchiyama S, Pill S, Bautista L, Yin L, Regan M, Chu E. Rabara T, Wong M, Fairman J, Nizet V. Click chemistry-based technology for site-specific polysaccharide conjugation allows a bacterial protein to serve as both carrier and vaccine antigen. ACS Omega 2022; 7:24111-24120.  ABSTRACT  |  PDF
Passos LSA, Nizet V, Levine RA, Aikawa E. Can we diagnose acute rheumatic fever early to maximize the success of secondary prophylaxis in rheumatic heart valve disease? Cardiovasc Res 2022; 118:e62-e65  ABSTRACT  |  PDF
Menon N, Penziner S, Montaño E, Zurich R, Pride D, Nair B, Kumar G, Nizet V. Increased innate immune susceptibility in hyperpigmented bacteriophage-resistant mutants of Pseudomonas aeruginosa. Antimicrob Agents Chemother 2022; July 6: e0023922 (online early)  ABSTRACT  |  PDF  |  Supplemental 
Hirose Y, Kolesinski P, Hiraoka M, Uchiyama S, Zurich RH, Kumaraswamy M, Bjanes E, Yamaguchi M, Sumitomo T, Ghosh P,  Kawabata S, Nizet V. Contribution of Streptococcus pyogenes M87 protein to innate immune resistance and virulence.  Microb Pathogen 2022; 169:105636  ABSTRACT  |  PDF
Kolesiński P, Wang KC, Hirose Y, Nizet V, Ghosh P. An M protein coiled coil unfurls and exposes its hydrophobic core to capture LL-37. ELife 2022; 11:e77989.  ABSTRACT  |  PDF
OpenForum-ID.jpg Gilbertie J, Ulloa ER, Daiker JC, Nguyen K, Smelter D, Rose W, Geriak M, Schnabel LV, Nizet V, Sakoulas G, Potent activity of ertapenem plus cefazolin within staphylococcal biofilms: a contributing factor in the treatment of methicillin-susceptible Staphylococcus aureus endocarditis. Open Forum Infect Dis 2022; 5:ofac59  ABSTRACT  |  PDF 
AAC.jpg Caffrey AR, Appaneal HJ, LaPlante KL, Lopes VV, Ulloa ER, Nizet V, Sakoulas G. Impact of clopidogrel on clinical outcomes in patients with Staphylococcus aureus bacteremia: A national retrospective cohort study. Antimicrob Agents Chemother 2022 Apr 13:e0211721 (online early)  ABSTRACT  |  PDF
Pashangeh S, Shekarforoush SS, Aminlari M, Hosseinzadeh S, Nizet V, Dahesh S, Rahmdel S. Inhibition of histamine accumulation by novel histamine degrading species of Staphylococcus sp. isolated from goats and sheep milk. Food Sci Nutr 2022; 10:354-362.  ABSTRACT  |  PDF
Moni M, Madathil T, Sathyapalan DT, Menon V, Gutjahr G, Edathadathil F, Sureshkumar D, Prasanna P, Jose S, Jerome R, Krishnan A, Pillai IC, Kumar G, Nair B, Nizet V, and Jayant A. Clinical efficacy of inhaled nitric oxide in preventing the progression of moderate to severe COVID-19 and its correlation to viral clearance—Results of a pilot study. Infect Microb Dis 2022; 4:26-33.  ABSTRACT   |  PDF
mSphere.png Mejia M, Ottinger S, Vrbanac A, Babu P, Zulk J, Moorshead D, Bode L, Nizet V, Patras K. Human milk oligosaccharides reduce murine group B Streptococcus vaginal colonization with minimal impact on the vaginal microbiota. mSphere 2022; 7:e00885-2.    ABSTRACT  |  PDF
Corriden R, Schmidt B, Olson J, Okerblom J, Masso Silva J, Nizet V, Meier A. Dexmedetomidine does not directly inhibit neutrophil extracellular trap production. Brit J Anaesthes 2022; 128:e51-e54.  ABSTRACT  |  PDF
JAC.jpg Holland ML, Bjanes E, Nizet V, Dillon NA. Bicarbonate modulates delafloxacin activity against multidrug-resistant Staphylococcus aureus and Pseudomonas aeruginosa. J Antimicrob Chemother  2022;77:433-442. ABSTRACT  |  PDF
Lee HW, Nizet V, An JN, Lee HS, Song YR, Kim SG, Kim JK. Uremic serum damages endothelium by provoking excessive neutrophil extracellular trap formation. Sci Rep 2021; 11:21439.  ABSTRACT  |  PDF
Campeau A, Uchiyama S, Sanchez C, Sauceda C, Nizet V, Gonzalez D. The S protein of group B Streptococcus is a critical virulence determinant that impacts the cell surface virulome. Front Microbiol 2021; 12:729308.  ABSTRACT  | PDF
Yamaguchi M, Kinjo Y, Nizet V. Editorial: Host-pathogen interactions during pneumococcal infection. Front Cell Infect Microbiol 2021; 11:752959. ABSTRACT  |  PDF
Kumaraswamy M, Wiull K, Joshi B, Sakoulas G, Kousha A, Vaaje-Kolstad G, Johannessen M, Hegstad K, Nizet V, Askarian F. Bacterial membrane-derived vesicles attenuate vancomycin activity against methicillin-resistant Staphylococcus aureus. Microorganisms 2021; 9:2055.  ABSTRACT  |  PDF
Golden G, Toledo A, Marki A, Sorrentino J, Morris C, Riley R, Spliid C, Chen Q, Cornax I, Lewis N, Varki N, Le D, Malmström J, Karlsson C, Ley K, Nizet V, Esko J. Endothelial heparan sulfate mediates hepatic neutrophil trafficking and injury during Staphylococcus aureus sepsis. mBio 2021; 12:e01181-21.  ABSTRACT  |  PDF
Gao NJ, Rodas Lima E, Nizet V. Immunobiology of the classical Lancefield group A streptococcal carbohydrate antigen. Infect Immun 2021; 89:e00292-21.  ABSTRACT  |  PDF
Kim JK, Uchiyama S, Gong H, Stream A, Zhang L, Nizet V. Engineered biomimetic platelet membrane-coated nanoparticles block Staphylococcus aureus cytotoxicity and protect against lethal systemic infection. Engineering 2021;  7:1149-1156.  ABSTRACT  |  PDF
Rada C, Mejia-Pena H, Grimsey N, Canto Cordova I, Olson J, Wozniak J, Gonzalez DJ, Nizet V, Trejo J. Heat Shock Protein 27 activity is linked to endothelial barrier resolution induced by GPCR pro-inflammatory mediators. Sci Signal 2021;14,:eabc1044 ABSTRACT  |  PDF  |  Press Release
Richter J, Monteleone M, Cork A, Barnett T, Nizet V, Brouwer S, Schroder K, Walker M. Streptolysins are the primary inflammasome activators in macrophages during Streptococcus pyogenes infection. Immunol Cell Biol 2021; 99:1040–1052   ABSTRACT  |  PDF
mSphere.png Sastry AV, Dillon N, Anand A, Poudel S, Hefner Y, Xu S, Szubin R, Feist AM, Nizet V, Palsson B. Machine learning of bacterial transcriptomes reveals responses underlying differential antibiotic susceptibility. mSphere 2021; 6:e0044321. ABSTRACT  | PDF
Machado H, Seif Y, Sakoulas G, Olson CA, Szubin R, Palsson BO, Nizet V, Adam M, Feist A. Environmental conditions dictate differential evolution of vancomycin resistance in Staphylococcus aureus. Commun Biol 2021; 4:793. ABSTRACT  |  PDF
CID.jpg Rose WE, Fantl M, Geriak M, Nizet V, Sakoulas G. Current paradigms of combination therapy in methicillin-resistant Staphylococcus aureus (MRSA) bacteremia: does it work, which combination and for which patients? Clin Infect Dis 2021; 73:2353–60.  ABSTRACT  |  PDF
Ulloa ER, Uchiyama S, Gillespie R, Nizet V, Sakoulas G. Ticagrelor increases platelet-mediated Staphylococcus aureus killing resulting in clearance of bacteremia. J Infect Dis 2021; 1224:1566–9. ABSTRACT |  PDF
Lum G, Mercado V, van Ens D, Nizet V, Kimmey JM, Patras KA. Hypoxia-inducible factor 1 alpha is dispensable for host defense of group B Streptococcus colonization and infection. J Innate Immun 2021; 13:391–403. ABSTRACT  |  PDF
Hirose Y, Yamaguchi M, Sumitomo T, Nakata M, Hanada T, Okuzaki D, Motooka D, Mori Y, Kawasaki H, Coady A, Uchiyama S, Hiraoka M,  Zurich RH, Amagai M, Nizet V, Kawabata S. Streptococcus pyogenes upregulates arginine metabolism to exert its pathogenesis on the skin surface. Cell Reports 2021; 34:108924.  ABSTRACT  |  PDF
Sun J, Uchiyama S, Olson J, Morodomi Y, Cornax I, Ando N, Kohno Y, Kyaw MMT, Aguilar B, Haste NM, Kanaji S, Kanaji T, Rose WE, Sakoulas G, Marth JD, Nizet V.  Repurposed drugs block toxin-driven platelet clearance by the hepatic Ashwell-Morell receptor to clear Staphylococcus aureus bacteremia. Sci Transl Med 2021; 13:eabd6737.  ABSTRACT  |  PDF  |  Supplemental | Press Release
Bier E, Nizet V. Driving to safety: CRISPR-based genetic approaches to reducing antibiotic resistance. Trends Genet 2021; 37:745-757.   ABSTRACT  |  PDF
Askarian F, Uchiyama S, Masson H, Bunaes AC, Golten O, Mekasha S, Røhr ÅK, Kommedal E, Ludviksen JA, Sørenson HV, Arntzen MØ, Schmidt B, van Sorge NM, Eijsink VG, Krengel U, Mollnes TE, Lewis NE, Nizet V, Vaaje-Kolstad G. The lytic polysaccharide monooxygenase CbpD promotes Pseudomonas aeruginosa virulence in systemic infection. Nat Commun 2021; 12:1230.  ABSTRACT  | PDF  |  Supplemental
Bjanes E, Nizet V. More than a pore: non-lytic antimicrobial functions of complement and bacterial strategies for evasion. Microbiol Mol Biol Rev 2021; 85:e00177-20.   ABSTRACT  |  PDF 
Saha S, Coady A, Sasmal A, Kawanishi K, Choudhury B, Yu H, Sorensen R, Inostroza J, Schoenhofen I, Chen X, Münster-Kühnel A, Sato C, Kitajima K, Ram S, Nizet V, Varki A. Exploring the impact of ketodeoxynonulosonic acid in host-pathogen interactions using uptake and surface display by nontypeable Haemophilus influenzae. mBio 2021; 12:e03226-20.  ABSTRACT  |  PDF
Cornax I, Zulk J, Olson J, Fulde M, Nizet V, Patras KA. Novel models of Streptococcus canis colonization and disease reveal modest contributions of M-like (SCM) protein. Microorganisms 2021; 9:183.  ABSTRACT  |  PDF
mSphere.png Menon ND, Kumar MS, Satheesh Babu TG, Bosee S, Vijayakumara G, Baswe M, Chatterjee M, D’Silva JR, Shetty K, Haripriyan J, Kumar A, Nair S, Somanath P, Nair BG, Nizet V, Kumar GB. A novel N4-like bacteriophage isolated from a wastewater source in South India with activity against several multidrug-resistant clinical Pseudomonas aeruginosa isolates. mSphere 2021; 6:e01215-20.  ABSTRACT  |  PDF 
Gao NJ, Uchiyama S, Pill L, Dahesh S, Olson J, Bautista L, Maroju S, Berges A, Liu JZ, Zurich RH, van Sorge NM, Fairman F, Kapoor N, Nizet V. Site-specific conjugation of cell wall polyrhamnose to protein SpyAD envisioning a safe universal group A streptococcal vaccine. Infect Dis Microb 2021; 3:87-100.  ABSTRACT  |  PDF
Rajput A, Poudel S, Tsunemoto H, Meehan M, Szubin R, Olson CA, Seif Y, Lamsa A, Dillon N, Vrbanac A, Sugie J, Dahesh S, Monk JM, Dorrestein PC, Knight R, Pogliano P, Nizet V, Feist AM, Palsson BO. Identifying the effect of vancomycin on healthcare-associated methicillin-resistant Staphylococcus aureus strains using bacteriological and physiological media. GigaScience 2021; 10:giaa156.  ABSTRACT  |  PDF
JEM.png Marki A, Buscher K, Lorenzini C, Meyer M, Saigusa R, Fan Z, Yeh YT, Hartmann N, Golden G, Dan J, Kiosses W, Ganesan R, Winkels H, Orecchioni M, McArdle S, Mikulski Z, Altman Y, Bui J, Kronenberg M, Esko J, Chien S, Nizet V, Smalley D, Roth J, Ley K. Elongated neutrophil-derived structures (ENDS) are novel blood borne microparticles formed by rolling neutrophils during sepsis. J Exp Med 2021; 218:e20200551.  ABSTRACT  |  PDF
Liu X, Kimmey JM, Matarazzo L, de Bakker V, Van Maele L, Sirard JC, Nizet V, Veening JW. Exploration of bacterial bottlenecks and Streptococcus pneumoniae pathogenesis by CRISPRi-seq. Cell Host Microbe 2021; 29:P107-120.E6 ABSTRACT  | PDF  |  Press Release
Wilde S, Olivares KL, Nizet V, Hoffman HM, Radhakrishna S, LaRock CN. Opportunistic invasive Infection by group A Streptococcus during anti-interleukin-6 immunotherapy. J Infect Dis 2021; 223:1260-1264.  ABSTRACT  |  PDF
Hirose Y, Yamaguchi M, Takemoto N, Miyoshi-Akiyama T, Sumitomo T, Nakata M, Ikebe T, Hanada T, Yamaguchi T, Kawahara R, Okuno R, Otsuka H, Matsumoto Y, Terashima Y, Kazawa Y, Nakanishi N, Uchida K, Akiyama Y, Iwabuchi K, Nakagawa C, Yamamoto K, Nizet V, Kawabata S. Genetic characterization of Streptococcus pyogenes emm89 strains isolated in Japan from 2011 to 2019.  Infect Microbe Dis 2020; 2:160-166.  ABSTRACT  |  PDF
JI.png Washington A, Varki N, Valderrama JA, Nizet V, Bui JD. Evaluation of interleukin-17D in host immunity to group A Streptococcus infection. J Immunol 2020; 205:3122-3129.   ABSTRACT  |  PDF
Swanson S, Katkar G, Tam J, Pranadinata R, Chareddy Y, Coates J, Olson J, Nizet V, Kufareva I, Das S, Castillo V, Ghosh P. TLR4 signaling and macrophage inflammatory responses are dampened by GIV/Girdin. Proc Natl Acad Sci USA 2020; 117:26895-26906.   ABSTRACT  |  PDF
CID.jpg Ulloa ER, Singh KV, Geriak M, Haddad F, Murray BE, Nizet V, Sakoulas G.  Cefazolin and ertapenem salvage therapy rapidly clears persistent methicillin-susceptible Staphylococcus aureus bacteremia. Clin Infect Dis 2020; 71:1413-1418. ABSTRACT | PDF
Vrbanac A, Patras KA, Jarmusch AK, Mills RH, Shing S, Quinn RA, Vargas F, Gonzalez DJ, Dorrestein PC, Knight R, Nizet V. Evaluating organism-wide changes in the metabolome and microbiome following a single dose of antibiotic.  mSystems 2020; 5:e00340-20.  ABSTRACT  |  PDF  |  Supplemental
Brouwer S, Barnett TC, Ly D, Kasper KJ, De Oliveira DM, Rivera-Hernandez T, Cork AJ, McIntyre L, Jespersen MG, Richter J, Schulz BL, Dougan G, Nizet V, Yuen KY, You Y, McCormick JK, Sanderson-Smith ML, Davies MR, Walker MJ. Prophage exotoxins enhance colonization fitness in epidemic scarlet fever-causing Streptococcus pyogenes. Nat Comm  2020; 11:5018.  ABSTRACT  |  PDF
Sun J, LaRock DL, Skowronski E, Kimmey JM, Olson J, Jiang Z, O’Donoghue AJ, Nizet V, LaRock CN. The Pseudomonas aeruginosa protease LasB directly activates IL-1β. EBiomedicine 2020; 60:102984. ABSTRACT  |  PDF
Wozniak JM, Mills RH, Olson J, Caldera JR, Poore GD, Carrillo-Terrazas M, Tsai CM, Vargas F, Knight R, Dorrestein PC, Liu GY, Nizet V, Sakoulas G, Rose W, Gonzalez DJ. Mortality risk profiling of Staphylococcus aureus bacteremia by multi-omic serum analysis reveals early predictive and pathogenic molecular signatures.  Cell 2020; 182:1067-1362.  ABSTRACT  |  PDF
Campeau A, Mills R, Blanchette M, Bajc K, Malfavon M, Munji R, Deng L, Hancock B, Patras K, Olson J, Nizet V, Daneman R, Doran K, and Gonzalez D.  Multi-dimensional proteome profiling of blood-brain barrier perturbation by group B Streptococcus. mSystems 2020; 5:e00368-20.  ABSTRACT  |  PDF
Chen YH, Li SH, Yang YC, Hsu SH, Nizet V, Chang YC. T4 pili promote colonization and immune evasion phenotypes of non-encapsulated M4 Streptococcus pyogenes. mBio 2020; 11: e01580-20.  ABSTRACT  |  PDF
OpenForum-ID.jpg Berti I, Rose WE, Nizet V, Sakoulas G.  Antibiotics and innate immunity: a cooperative effort towards the successful treatment of infections.  Open Forum Infect Dis 2020; 7:ofaa302.  ABSTRACT  |  PDF
CID.jpg Volk CF, Burgdorf S, Edwarson GW, Nizet V, Sakoulas G, Rose W. IL-1β and IL-10 host responses in patients with Staphylococcus aureus bacteremia determined by antimicrobial therapy.  Clin Infect Dis 2020; 70:2634-2640  ABSTRACT  |  PDF
Woehl JL, Kitamura S, Dillon N, Edgar LJ, Han Z, Nizet V, Wolan DW. An irreversible inhibitor to probe the role of Streptococcus pyogenes cysteine protease SpeB in evasion of host complement defenses.  ACS Chem Biol 2020; 15: 2060-2069.  ABSTRACT   |  PDF
Poudel S, Tsunemoto H, Seif Y, Sastry AV, Szubin R, Xu S, Machado H, Olson CA, Anand A, Pogliano J, Nizet V, Palsson BO. Revealing 29 sets of independently modulated genes in Staphylococcus aureus, their regulators and role in key physiological responses. Proc Natl Acad Sci 2020; 117:17228-17239.  ABSTRACT  |  PDF  |  Supplemental
Kitamura S, Zheng Q, Woehl, J, Solania A, Chen E, Dillon N, Hull M, Kotaniguchi M, Cappiello J, Kitamura S, Nizet V, Sharpless KB, Wolan D. Sulfur(VI) fluoride exchange (SuFEx)-enabled high-throughput medicinal chemistry. J Am Chem Soc 2020; 142:10899-10904.   ABSTRACT  |  PDF  |  Supplemental
Li Y, Fin A, Rovira A, Su Y, Dippel A, Valderrama JA, Riestra A, Nizet V, Hammond MC, Tor Y. Tuning the innate immune response to cyclic dinucleotides using atomic mutagenesis. ChemBioChem 2020; 21:2595-2598.  ABSTRACT  |  PDF
Lund SJ, Patras KA, Kimmey JM, Yamamura A, Butcher LD, Del Rosario PG, Hernandez GE, McCoy AM, Lakhdari O, Nizet V, Prince LS. Developmental immaturity of Siglec receptor expression on neonatal alveolar macrophages predisposes to severe group B streptococcal infection. iScience 2020; 23:101207.  ABSTRACT  |  PDF
Shewell LK, Day CJ, Jen FE, Haselhorst T, Atack JM, Reijneveld JF, Everest-Dass A, James DB, Boguslawski KM, Brouwer S, Gillen CM, Luo Z, Kobe B, Nizet V, von Itzstein M, Walker MJ, Adrienne W. Paton AW, Paton JC, Torres VJ,  Jennings MP. All major cholesterol-dependent cytolysins use glycans as cellular receptors.  Sci Adv 2020; 6:eaaz4926.  ABSTRACT  |  PDF
mSphere.png Patras K, Coady A, Babu P, Shing S, Ha A, Rooholfada E, Brandt S, Geriak M, Gallo RL, Nizet V. Host cathelicidin exacerbates group B Streptococcus urinary tract infection. mSphere 2020; 5:e00932-19.  ABSTRACT  |  PDF
Lawrence SM, Corriden R, Nizet V. How neutrophils meet their end.  Trends Immunol 2020; 41:531-544.  ABSTRACT  |  PDF
Salazar M, Machado H, Dillon N, Tsunemoto H, Szubin R, Dahesh S, Pogliano J, Sakoulas G, Palsson BO, Nizet V, Feist A. Genetic determinants enabling media-dependent adaptation to nafcillin in methicillin-resistant Staphylococcus aureus.  mSystems 2020; 5:e00828-19.  ABSTRACT  |  PDF
Chang YC, Nizet V. Siglecs at the host-pathogen interface. Adv Exp Med Biol 2020; 1204:197-214.  ABSTRACT  |  PDF
Lee HS, Park MJ, Yoon SY, Joo N, Song YR, Kim HJ, Kim SG, Nizet V, Kim JK. Role of peribrachial fat as a key determinant of brachial artery dilatation for successful arteriovenous fistula maturation in hemodialysis patients.  Sci Rep 2020; 10:3841. ABSTRACT  |  PDF
Quinn RA, Melnik AV, Vrbanac A, Fu T, Patras KA, Christy MP, Bodai Z, Belda-Ferre P, Tripathi A, Chung LK, Downes M, Welch RD, Quinn M, Humphrey G, Panitchpakdi M, Weldon KC, Askenov A, da Silva R, Avila-Pacheco J, Clish C, Bae S, Mallick H, Franzosa EA, Lloyd-Price J, Bussell R, Thron T, Nelson AT, Wang M, Leszczynski E, Vargas F, Gauglitz JM, Meehan MJ, Gentry E, Arthur TD, Komor AC, Poulsen O, Boland BS, Chang JT, Sandborn WJ, Lim M, Garg N, Lumeng JC, Xavier RJ, Kazmierczak BI, Jain R, Egan M, Rhee KE, Ferguson D, Raffatellu M, Vlamakis H, Haddad GG, Siegel D, Huttenhower C, Mazmanian SK, Evans RM, Nizet V, Knight R, Dorrestein PC. Global chemical impacts of the microbiome include novel bile acid conjugations.  Nature 2020;  579:123–129.  ABSTRACT  |  PDF  |  Press Release
Ulloa ER, Kousha A, Tsunemoto H, Pogliano J, Licitra C, LiPuma JJ, Sakoulas G, Nizet V, Kumaraswamy M. Azithromycin exerts bactericidal activity and enhances innate immune-mediated killing of MDR Achromobacter xylosoxidans. Infect Microb Dis 2020; 2:10-17.  ABSTRACT  |  PDF
FrontCellInfect.jpg Shing SR, Ramos AR, Patras KA, Riestra AM, McCabe S, Nizet V, Coady A.  The fungal pathogen Candida albicans promotes bladder colonization of group B Streptococcus.  Front Cell Infect Microbiol 2020; 9:437.  ABSTRACT  |  PDF  |  Supplemental
Denholtz M, Zhu Y, He Z, Lu H, Isoda T, Döhrmann S, Nizet V, Murre C.  Upon microbial challenge, human neutrophils undergo rapid changes in nuclear architecture and chromatin folding to orchestrate an immediate inflammatory gene program. Genes Dev 2020; 34:149-165.  ABSTRACT  |  PDF  |  Supplemental |  Cover Article
Rajput A, Poudel S, Tsunemoto H, Meehan M, Szubin R, Olson C, Lamsa A, Seif Y, Dillon N, Vrbanac V, Sugie J, Dahesh S, Monk J, Dorrestein P, Knight R, Nizet V, Palsson B, Feist A, Pogliano J. Profiling the effect of nafcillin on HA-MRSA D712 using bacteriological and physiological media. Sci Data 2019; 6:322.  ABSTRACT  |  PDF
Tacke R, Sun J, Uchiyama S, Polovina A, Nguyen DG, Nizet V. Protection against lethal multidrug-resistant bacterial infections using macrophage cell therapy. Infect Microb Dis 2019; 1:61-69. ABSTRACT  |  PDF 
Tsai CM, Riestra AM, Ali SR, Fong JJ, Liu JZ, Hughes G, Varki A, Nizet V. Siglec-14 enhances NLRP3-inflammasome activation in macrophages. J Innate Immun 2019; 11:86-98. ABSTRACT  |  PDF |  Supplemental
Valderrama JA, Kulkarni SS, Nizet V*, Bier E*. A bacterial gene-drive system efficiently edits and inactivates a high copy number antibiotic resistance locus. Nat Comm 2019; 10:5726. ABSTRACT  |  PDF |  Supplemental
Koo J, Escajadillo T, Zhang L, Nizet V, Lawrence SM. Erythrocyte-coated nanoparticles block cytotoxic effects of group B Streptococcus β-hemolysin/cytolysin. Front Pediatr 2019; 7:410. ABSTRACT  |  PDF 
Gomez Toledo A, Golden G, Rosa-Campos A, Cuello H, Sorrentino J, Lewis N, Varki N, Nizet V, Smith JW, Esko JD. Proteomic atlas of organ vasculopathies triggered by Staphylococcus aureus sepsis. Nat Comm 2019; 10:4656. ABSTRACT  |  PDF 
Machado H, Weng L, Dillon N, Seif Y, Holland M, Pekar J, Monk J, Nizet V, Palsson B, Feist A. A defined minimal medium for systems analyses of Staphylococcus aureus reveals strain-specific metabolic requirements. Appl Environ Microbiol 2019; 85:e01773-19. ABSTRACT  |  PDF
CID.jpg Volk CF, Burgdorf S, Edwardson G, Nizet V, Sakoulas G, Rose WE. IL-1β and IL-10 host reponses in patients with Staphylococcus aureus bacteremia determined by antimicrobial therapy. Clin Infect Dis 2019; 70:2634-2640. ABSTRACT  |  PDF
Gao NJ, Al-Bassam MM, Poudel S, Wozniak JM, Gonzalez DJ, Olson J, Zengler K, Nizet V, Valderrama JA. Functional and proteomic analysis of Streptococcus pyogenes virulence upon loss of its native Cas9 nuclease. Front Microbiol 2019; 10:1967. ABSTRACT  |    Supplemental   |  PDF
Cohen-Katsenelson K, Stender JD, Uchiyama S, Grezchnik AT, Nizet V, Glass CK, Newton AC. PHLPP1 counterregulates STAT1-mediated inflammatory signaling. eLife 2019; 8:e48609. ABSTRACT  |  PDF
Dillon N, Holland M, Tsenemoto H, Hancock B, Cornax I, Pogliano J, Sakoulas G, Nizet V. Surprising synergy of dual translation inhibition vs. Acinetobacter baumannii and other multidrug-resistant bacterial pathogens eBiomedicine 2019; 46:193-201. ABSTRACT  |  PDF
LaRock DL, Sands J, Ettouati E, Richard M, Bushway PJ, Adler ED, Nizet V, LaRock CN. Inflammasome inhibition blocks cardiac glycoside cell toxicity. J Biol Chem 2019; 294:12846-12854. ABSTRACT  |  PDF
Rivera-Hernandez T, Carnathan D, Jones S, Cork A, Davies M, Moyle P, Toth I, Batzloff M, McCarthy J, Nizet V, Goldblatt D, Silvestri G, Walker MJ. An experimental group A Streptococcus vaccine that reduces pharyngitis and tonsillitis in a non-human primate model. mBio 2019 10:e00693-19. ABSTRACT  |  PDF  |  Supplemental
FrontPharm.png Meier A, Chien J, Hobohm L, Patras KA, Nizet V, Corriden R. Inhibition of human neutrophil extracellular trap (NET) production by propofol and lipid emulsion. Front Pharmacol 2019; 10:323. ABSTRACT  |  PDF
Ulloa ER, Dillon N, Tsunemoto H, Pogliano J, Sakoulas G, Nizet V. Avibactam sensitizes carbapenem-resistant NDM-1-producing Klebsiella pneumoniae to innate immune clearance. J Infect Dis 2019 220:484-493. ABSTRACT  |  PDF   |   Supplemental
Patras KA, Ha AD, Rooholfada E, Olson J, RamachandraRao SP, Lin AE, Nizet V. Augmentation of urinary lactoferrin enhances host innate immune clearance of uropathogenic E. coli. J Innate Immun 2019; 11:481-495. ABSTRACT  |  PDF |  Supplemental
AAC.jpg Dahesh S, Wong B, Nizet V, Sakoulas G (Discussion by Tran TT, Aitken SL. Treatment of multi-drug resistant vancomycin-resistant Enterococcus faecium hardware-associated vertebral osteomyelitis with oritavancin plus ampicillin. Antimicrob Agents Chemother 2019; 63:e02622-18. ABSTRACT  |  PDF
Uchiyama S, Sun J, Fukahori K, Wu M, Varki A, Marth JD, Nizet V. Dual actions of group B Streptococcus capsular sialic acid provide resistance to platelet-mediated antimicrobial killing. Proc Natl Acad Sci USA 2019; 116:7465- 7470. ABSTRACT  |  PDF
EMBO.png Zhang Q, Chao TC, Patil VS, Qin Y, Kant Tiwari S, Chiou J, Dobin A, Tsai CM, Li Z, Dang J, Gupta S, Urdahl K, Nizet V, Gingeras TR, Gaulton K, Rana TM. A cis-acting long noncoding RNA ROCKI regulates inflammatory gene expression. EMBO J 2019; 38:e100041. ABSTRACT  |  PDF
Poudel S, Tsunemoto H, Meehan M, Szubin R, Olson C, Lamsa A, Seif Y, Dillon N, Vrbanac A, Sugie J, Dahesh S, Monk J, Dorrestein P, Pogliano J, Knight R, Nizet V, Palsson B, Feist A. Characterization of CA-MRSA TCH1516 exposed to nafcillin in bacteriologic and physiologic media. Sci Data 2019; 6:43. ABSTRACT  |  PDF
Caffrey AR, Timbrook TT, Ali SR, Nizet V, Sakoulas G. Proton pump inhibitors do not influence clinical outcomes in patients with Staphylococcus aureus bacteremia. Therap Adv Gastroenterol 2019; 12:1756384819834273. ABSTRACT  |  PDF
AAC.jpg Geriak M, Haddad F, Rizvi K, Rose W, Kullar R, LaPlante K, Yu M, Vasina L, Oueletter K, Zervos M, Nizet V, Sakoulas G. Clinical data on daptomycin plus ceftaroline versus standard of care monotherapy in the treatment of methicillin-resistant Staphylococcus aureus bacteremia. Antimicrob Agents Chemother 2019; 63:e02483-18. ABSTRACT  |  PDF
Bauman KD, Li J, Murata K, Mantovani SM, Dahesh S, Nizet V, Luhavaya H, Moore BS. Refactoring the cryptic streptophenazine biosynthetic gene cluster unites phenazine, polyketide, and nonribosomal peptide biochemistry. Cell Chem Biol 2019; 6:724-736. ABSTRACT  |  PDF   |  Supplemental
Nerlich A, Lapschies AM, Kohler TP, Cornax I, Eichhorn I, Goldmann O, Krienke P, Bergmann S, Nizet V, Hammerschmidt S, Rohde M, Fulde M. Homophilic protein interactions facilitate bacterial aggregation and IgG dependent complex formation by the Streptococcus canis M protein SCM. Virulence 2019; 10:194-206. ABSTRACT  |  PDF
CID.jpg Walker MJ, Brouwer S, Forde BM, Worthing KA, McIntyre L, Sundac L, Maloney S, Roberts LW, Barnett TC, Richter J, Cork AJ, Irwin AD, You Y, Zhang J, Dougan G, Yuen KY, Nizet V, Beatson SA, Grimwold K, Davies MR. Detection of epidemic scarlet fever group A Streptococcus in Australia. Clin Infect Dis 2019; 69:1232-1234. ABSTRACT  |  PDF
Huang YM, Munguia J, Miao Y, Nizet V, McCammon JA. Docking simulation and antibiotic discovery targeting the MlaC protein in Gram-negative bacteria. Chem Biol Drug Des 2019; 93:647-652. ABSTRACT  |  PDF
Boeltz S, Amini P, Anders HJ, Andrade F, Bilyy R, Chatfield S, Cichon I, Clancy DM, Desai J, Dumych T, Dwivedi N, Gordon RA, Hahn J, Hidalgo A, Hoffman MH, Kaplan MJ, Knight JS, Kolaczkowska E, Kubes P, Leppkes M, Manfredi AA, Martin SJ, Maueröder C, Maugeri N, Mitroulis I, Munoz LE, Nakazawa D, Neeli I, Nizet V, Pieterse E, Radic MZ, Reinwald C, Ritis K, Rovere- Querini P, Santocki M, Schauer C, Schett G, Shlomchik MJ, Simon HU, Skendros P, Stojkov D, Vandenabeele P, Vanden Berghe T, van der Vlag J, Vitkov L, von Köckritz- Blickwede M, Yousefi S, Zarbock A, Herrmann M. To NET or not to NET: Current opinions and state of the science regarding the formation of neutrophil extracellular traps. Cell Death Differ 2019; 26:395-408. ABSTRACT  |  PDF  |  Supplemental
Dan JM, Dr. Colin Havenar-Daughton C, Kendric K, Kaushik K, Rosales S, Anderson E, LaRock C, Pandurangan V, Seumois G, Layfield D, Cutress R, Ottensmeier C, Lindestam Alrehman C, Sette A, Nizet V, Bothwell M, Brigger M, Crotty S. Recurrent tonsillitis is an immunosusceptibility disease involving antibody deficiency and aberrant TFH cells. Sci Transl Med 2019; 11:eaau3776. ABSTRACT  |  PDF   |  Supplemental
Meier A, Nizet V. Impact of anesthetics on human neutrophil function. Anesth Analg 2019; 128:569-574. ABSTRACT  |  PDF
Riestra AM, Valderrama JA, Patras KA, Booth SD, Quek X, Tsai CM, Nizet V. Trichomonas vaginalis induces NLRP3 inflammasome activation and pyroptosis in human macrophages. J Innate Immun 2019; 11:86-98. ABSTRACT  |  PDF
CID.jpg Sakoulas G, Geriak M, Nizet V. Is a question of penicillin allergy sufficient grounds to forgo the multidimensional antimicrobial benefits of β-lactam antibiotics? Clin Infect Dis 2019; 68:157-164. ABSTRACT  |  PDF
Escajadillo T, Nizet V. Pharmacological targeting of pore-forming toxins as adjunctive therapy for invasive bacterial infections. Toxins 2018; 10:542. ABSTRACT  |  PDF
Vrbanac A, Riestra A, Coady A, Knight R, Nizet V, Patras KA. The murine vaginal microbiota and perturbation by the human pathogen group B Streptococcus. BMC Microbiol 2018; 18:197. ABSTRACT  |  PDF  |   Supplemental
IntJpharm.jfif Uchiyama S, Dahesh S, Nizet V, Kessler J. Enhanced topical delivery of non-complexed molecular iodine for methicillin-resistant Staphylococcus aureus decolonization. Int J Pharmaceut 2018; 554:81-86. ABSTRACT  |  PDF
Coady A, Ramos AR, Olson J, Nizet V, Patras KA. Tamm-Horsfall protein protects the urinary tract against Candida albicans. Infect Immun 2018; 86:e00451-18. ABSTRACT  |  PDF
PlosPath.png van Hensbergen VP, Movert E, de Maat V, Le Breton Y, Lambeau G, Payre C, Kahn F, Henningham A, Nizet V, Van Strijp JA, Carlsson F, McIver KS, van Sorge NM. Streptococcal Lancefield polysaccharides are critical cell wall determinants for human group IIA secreted phospholipase A2 to exert its bactericidal effects. PLoS Pathogens 2018; 14:e1007348. ABSTRACT  |  PDF   |  Supplemental
Kavvas E, Catoiu E, Mih N, Yurkovich J, Seif Y, Dillon N, Heckmann D, Anand A, Yang L, Nizet V, Monk J, Palsson BO. Machine learning and structural analysis of Mycobacterium tuberculosis pan-genome identifies genetic signatures of antibiotic resistance. Nat Commun 2018; 9:4306. ABSTRACT  |  PDF  |  Supplemental
Yang WH, Heithoff DM, Aziz P, Haslund-Gourney B, Westman JS, Narisawa S, Pinkerton AB, Millan JL, Nizet V, Mahan MJ, Marth JD. Accelerated aging and clearance of host anti-inflammatory enzymes by discrete pathogens fuels sepsis. Cell Host Microb 2018; 24:500-513. ABSTRACT  |  PDF   |  Supplemental
Fong J, Tsai CM, Saha S, Nizet V, Varki A, Bui J. Siglec-7 engagement by GBS β-protein suppresses pyroptotic cell death of natural killer cells. Proc Natl Acad Sci 2018; 115:10410-10415. ABSTRACT  |  PDF  |  Supplemental
Patras KA, Derieux J, Al-Bassam MM, Adiletta N, Vrbanac A, Lapek JD, Zengler K, Gonzalez DJ, Nizet V. Group B Streptococcus biofilm regulatory protein A contributes to bacterial physiology and innate immune resistance. J Infect Dis 2018; 218:1641-1652. ABSTRACT  |  PDF.  |  Supplemental
FEMS.png Askarian F, Wagner T, Johannessen M, Nizet V. Staphylococcus aureus modulation of innate immune responses through Toll-like (TLR), (NOD)-like (NLR) and C-type lectin (CLR) receptors. FEMS Microbiol Rev 2018; 42:656-671. ABSTRACT  |  PDF
PlosPath.png Alisson-Silva F, Liu J, Diaz S, Deng L, Gareau M, Chen X, Nizet V, Varki N, Barrett K, Varki A. Human evolutionary loss of epithelial Neu5Gc expression and the species-specific susceptibility to cholera. PLoS Pathogens 2018; 14:e1007133. ABSTRACT  |  PDF  |  Supplemental
AppMicroBioltech.jfif Kumaraswamy M, Collignon S, Do C, Kim J, Nizet V, Friend J. Decontaminating surfaces with atomized disinfectants generated by a novel thickness-mode lithium niobate device. Appl Microbiol Biotechnol 2018; 102:6459-6467. ABSTRACT  |  PDF  |  Supplemental
FrontCellInfect.jpg Soderholm AT, Barnett TC, Korn O, Hernandez TR, Seymour LM, Schulz BL, Nizet V, Wells CA, Sweet MJ, Walker MJ. Group A Streptococcus M1T1 intracellular infection of primary tonsil epithelial cells dampens levels of secreted IL-8 through the action of SpyCEP. Front Cell Infect Microbiol 2018; 8:160. ABSTRACT  |  PDF  |  Supplemental
frontMed.jfif Gupta N, Nizet V. Stabilization of hypoxia-inducible factor 1-alpha augments the therapeutic capacity of bone marrow-derived mesenchymal stem cells in experimental pneumonia. Front Med 2018; 5:131. ABSTRACT  |  PDF   |  Supplemental
Jati S, Kundu S, Chakraborty A, Mahata SK, Nizet V, Sen M. Wnt5A signaling promotes defense against bacterial pathogens by activating a host autophagy circuit. Front Immunol 2018; 9:679. ABSTRACT  |  PDF  |  Supplemental
JAC.jpg Gupta N, Liu R, Shin S, Sinha R, Pogliano J, Pogliano K, Griffin JH, Nizet V, Corriden R. SCH79797 improves outcomes in experimental bacterial pneumonia by boosting neutrophil killing and direct antibiotic activity. J Antimicrob Chemother 73:1586-1594. ABSTRACT  |  PDF  |  Supplemental
BenefMicrob.jfif van den Broek MFL, De Boeck I, Claes IJJ, Nizet V, Lebeer S. Multifactorial inhibition of lactobacilli against the respiratory tract pathogen Moraxella catarrhalis. Benef Microbes 2018; 9:429-439. ABSTRACT  |  PDF
Monogue M, Sakoulas G, Nizet V, Nicolau D. Humanized exposures of a β-lactam-β-lactamase inhibitor, tazobactam, versus non-β-lactam-β-lactamase inhibitor, avibactam, with or without colistin, against Acinetobacter baumannii in murine thigh and lung infection models. Pharmacology 2018; 101:255-261. ABSTRACT  |  PDF
FrontImmunol.jpg Askarian F, Lapek JD, Tsai CM, Kumaraswamy M, Kousha A, Valderrama JA, Ludviksen JA, Cavanagh PJ, Uchiyama S, Mollnes TE, Gonzalez DJ, Wai SN, Nizet V, Johannessen M. Staphylococcus aureus membrane- derived vesicles promote bacterial virulence and confer protective immunity in murine infection models. Front Microbiol 2018; 9:262. ABSTRACT  |  PDF
Patras KA, Nizet V. Group B streptococcal maternal colonization and neonatal disease: molecular mechanisms and preventative approaches. Front Pediatr 2018; 6:27. ABSTRACT  |  PDF
AdvHealthMat.jfif Chen Y, Chen M, Zhang Y, Lee JH, Escajadillo T, Gong H, Fang RH, Gao W, Nizet V, Zhang L. Broad-spectrum neutralization of pore-forming toxins with human erythrocyte membrane-coated nanosponges. Adv Health Mater 2018; 7:e1701366. ABSTRACT  |  PDF
Choe D, Szubin R, Dahesh S, Cho S, Nizet V, Palsson BO, Cho BK. Genome-scale analysis of community-acquired methicillin-resistant Staphylococcus aureus USA300 reveals a tradeoff between pathogenesis mechanisms and antibiotic resistance. Sci Rep 2018; 8:2215. ABSTRACT  |  PDF
Haripriyan J, Omanakuttan A, Menon ND, Vanuopadath M, Nair SS, Corriden R, Nair BG, Nizet V, Kumar GB. Clove bud oil modulates pathogenicity phenotypes of the opportunistic human pathogen Pseudomonas aeruginosa. Sci Rep 2018; 8:3437. ABSTRACT  |  PDF
Lawrence SM, Corriden R, Nizet V. The ontogeny of a neutrophil: mechanisms of granulopoiesis and homeostasis. Mol Biol Microbiol Rev 2018; 82:e00057-17. ABSTRACT  |  PDF
StemCells.jfif Gupta N, Sinha R, Krasnodembskaya A, Xu X, Nizet V, Matthay MA, Griffin JH. The TLR4-PAR1 axis regulates bone marrow mesenchymal stromal cell survival and therapeutic capacity in experimental bacterial pneumonia. Stem Cells 2018; 36:796-806. ABSTRACT  |  PDF
Henningham A, Davies MR, Uchiyama S, Van Sorge NM, Lund S, Bannon K, Walker MJ, Cole JN, Nizet V. Virulence role of the GlcNAc sidechain of the Lancefield cell wall carbohydrate antigen in non-M1 serotype group A Streptococcus. mBio 2018; 9:e02294-17. ABSTRACT  |  PDF
Kumaraswamy M, Do C, Sakoulas G, Nonejuie P, Tseng GW, King H, Fierer J, Pogliano J, Nizet V. Listeria monocytogenes endocarditis: Case report, review of the literature, and laboratory evaluation of potential novel antibiotic synergies. Int J Antimicrob Agents 2018; 51:468-478. ABSTRACT  |  PDF  |  Supplemental
JAC.jpg Britt N, Tirmizi S, Ritchie D, Topal J, McManus D, Nizet V, Casabar E, Sakoulas G. Telavancin for refractory methicillin-resistant Staphylococcus aureus bacteremia in intermittent hemodialysis recipients. J Antimicrob Chemother 2018; 73: 764-767. ABSTRACT  |  PDF
JNatProd.png Mascuch SJ, Boudreau PD, Carland TM, Pierce NT, Olson J, Hensler ME, Choi H, Campanale J, Hamdoun A, Nizet V, Gerwick WH, Gaasterland T, Gerwick L. Marine natural product honaucin A attenuates inflammation by activating the Nrf2-ARE pathway. ABSTRACT  |  PDF  |  Supplemental
FrontCellInfect.jpg Liu JZ, Ali SR, Bier E, Nizet V. Innate immune interactions between Bacillus anthracis and host neutrophils. Front Cell Infect Microbiol 2018; 8:2. ABSTRACT  |  PDF  |  Supplemental
FutureMicro.jfif Valderrama JA, Nizet V. Group A Streptococcus encounters with host macrophages. Future Microbiol 2018; 13:119- 134. ABSTRACT  |  PDF
Mesci P, Macia A, LaRock CN, Tejwani L, Fernandes IR, Suarez NA, Zanotto PM, Beltrão-Braga PC, Nizet V, Muotri AR. Modeling neuro-immune interactions during Zika virus infection. Human Mol Genet 2018; 27:41-52. ABSTRACT  |  PDF
Andreoni, F, Ugolini F, Keller N, Neff A, Nizet V, Hollands A, Marques-Maggio E, Zinkernagel A, Schuepbach R. Immunoglobulin attenuates streptokinase-mediated virulence in Streptococcus dysgalactiae subsp. equisimilis necrotizing fasciitis. J Infect Dis 2018; 217:270-279. ABSTRACT  |  PDF
Reynolds KA, Dahesh S, Nizet V, Moore BS. Isolation and structure elucidation of taromycin B from the activated taromycin biosynthetic gene cluster. J Antibiot 2017; 71: 333 – 338. ABSTRACT  |  PDF
Catteau L, Reichmann NT, Olson J, Pinho M, Nizet V, van Bambeke F, Quetin-LeClercq J. Synergy between ursolic and oleanolic acids from Vitellaria paradoxa leaf extract and β-lactams against methicillin-resistant Staphylococcus aureus: in vitro and in vivo activity and underlying mechanisms. Molecules 2017; 22:2245. ABSTRACT  |  PDF
Yang WH, Heithoff DM, Aziz PV, Sperandio M, Nizet V, Mahan MJ, Marth JD. Recurrent Salmonella infection progressively disables host protection against intestinal inflammation. Science 2017; 358:eaao5610. ABSTRACT  |  PDF  |  Supplemental
mSphere.png Sakoulas G, Kumaraswamy M, Kousha A, Nizet V. Interaction of antibiotics with innate host defense factors against Salmonella enterica serotype Newport. mSphere 2017; 2:e00410-17. ABSTRACT  |  PDF
Zhang Y, Gao W, Chen Y, Escajadillo T, Ungerleider JL, Fang RH, Christman KL, Nizet V, Zhang L. Self-assembled colloidal gel using cell membrane-coated nanosponges as building blocks. ACS Nano 2017; 11:11923-11930. ABSTRACT  |  PDF
Thamphiwatana S, Angsantikul P, Escajadillo T, Zhang Q, Olson J, Luk BT, Zhang S, Fang RH, Gao W, Nizet V, Zhang L. Macrophage-like nanoparticles concurrently absorbing endotoxins and proinflammatory cytokines for sepsis management. Proc Natl Acad Sci USA 2017; 114:11488–11493. ABSTRACT  |  PDF
PlosPath.png Guichard A, Jain P, Moayeri M, Schwarz R, Chin S, Zhu L, Cruz-Moreno B, Liu JZ, Aguilar B, Hollands A, Leppla SH, Nizet V, Bier E. Anthrax edema toxin disrupts distinct steps in Rab11-dependent junctional transport. PLoS Pathog 2017; 13:e1006603. ABSTRACT  |  PDF.  |  Supplemental
Sun J, Lei L, Tsai CM, Wang Y, Shi Y, Ouyang M, Lu S, Seong J, Kim T, Wang P, Huang M, Xu X, Nizet V, Chien S, Wang Y. Engineered proteins with sensing and activating modules for automated reprogramming of cellular functions. Nat Commun 2017; 8:477. ABSTRACT  |  PDF
AAC.jpg Schooley R, Biswas B, Gill J, Hernandez-Morales A, Lancaster J, Lessor L, Barr J, Reed S, Rohwer F, Benler S, Segall A, Taplitz R, Smith D, Kerr K, Kumaraswamy M, Nizet V, Lin L, McCauley M, Strathdee S, Benson C, Leroux B, Pope R, Picel A, Mateczun A, Cilwa K, Regeimbal J, Estrella L, Wolfe D, Henry M, Quinones J, Salka S, Bishop-Lilly K, Young R, Hamilton T. Development and use of personalized bacteriophage-based therapeutic cocktails to treat a patient with a disseminated resistant Acinetobacter baumannii infection. Antimicrob Agents Chemother 2017; 61:e00954-17. ABSTRACT  |  PDF  |  Supplemental
Munguia J, LaRock D, Tsunemoto H, Olson J, Pogliano P, Nizet V. The Mla pathway is critical for Pseudomonas aeruginosa resistance to outer membrane permeabilization and host innate immune clearance. J Mol Med 2017; 95:1127–1136. ABSTRACT  |  PDF
Patras KA, Coady A, Olson J, Ali SR, RamachandraRao S, Varki A, Nizet V. Tamm-Horsfall glycoprotein engages human Siglec-9 to modulate neutrophil activation in the urinary tract. Immunol Cell Biol 2017; 95:960-965. ABSTRACT    |  Supplemental   |  PDF
Valderrama JA, Riestra A, Gao NJ, LaRock CN, Gao NJ, Gupta N, Ali SR, Hoffman HM, Ghosh P, Nizet V. Group A streptococcal M protein activates the NLRP3 inflammasome. Nat Microbiol 2017; 2;1425–1434. ABSTRACT  |  PDF   |  Supplemental  |  News and Views
Nizet V. The accidental orthodoxy of Drs. Mueller and Hinton. EBiomedicine 2017; 22:26-27. ABSTRACT  |  PDF
Severino P, Ariga SK, Barbeiro HV, de Lima TM, de Paula Silva E, Barbeiro DF, Machado MC, Nizet V, Pinheiro da Silva F. Cathelicidin-deficient mice exhibit increased survival and upregulation of key inflammatory response genes following cecal ligation and puncture. J Mol Med 2017; 95:995–1003. ABSTRACT  |  PDF
Escajadillo T, Olson J, Luk BT, Zhang L, Nizet V. A red blood cell membrane-camouflaged nanoparticle counteracts streptolysin O-mediated virulence phenotypes of invasive group A Streptococcus. Front Pharmacol 2017; 8:477. ABSTRACT  |  PDF  |  Supplemental
Blood.png Lizcano A, Secundino I, Döhrmann S, Corriden R, Deng L, Diaz S, Nizet V, Varki A. Erythrocyte sialoglycoproteins engage Siglec-9 on neutrophils to suppress activation. Blood 2017; 29:3100-3110. ABSTRACT  |  PDF
Lin AE, Autran CA, Szyszka A, Escajadillo T, Huang M, Godula K, Prudden AR, Boons GJ, Lewis AL, Doran KS, Nizet V, Bode L. Human milk oligosaccharides inhibit growth of group B Streptococcus. J Biol Chem 2017; 92;11243–11249. ABSTRACT  |  PDF
CID.jpg Rose WE, Berti AD, Hayney MS, Henriquez K, Ranzoni A, Cooper MA, Shukla SK, Proctor RA, Nizet V, Sakoulas G. Increased endovascular Staphylococcus aureus inoculum is the link between elevated serum IL-10 concentrations and mortality in patients with bacteremia. Clin Infect Dis 2017; 64:1406-1412. ABSTRACT  |  PDF
Lawrence SM, Corriden R, Nizet V. Age-appropriate functions and dysfunctions of the neonatal neutrophil. Front Pediatr 2017; 5:23. ABSTRACT  |  PDF
Munguia J, Nizet V. Pharmacological targeting of the host-pathogen interaction: Alternatives to classical antibiotics to combat drug-resistant superbugs. Trends Pharm Sci 2017; 38:473-488. ABSTRACT  |  PDF
Döhrmann S, LaRock CN, Anderson EL, Cole JN, Ryali B, Stewart C, Nonejuie P, Pogliano J, Corriden R, Ghosh P, Nizet V. Group A streptococcal M1 protein provides resistance against the antimicrobial activity of histones. Sci Rep 2017; 7:43039. ABSTRACT  |  PDF   |  Supplemental
JI.png Okerblom J, Schwarz F, Olson J, Fletes W, Ali SR, Martin PT, Glass CK, Nizet V, Varki A. Loss of CMAH during human evolution primed the monocyte-macrophage lineage towards a more inflammatory and phagocytic state. J Immunol 2017; 198:2366-2373. ABSTRACT  |  PDF.
EMBO.png Schwarz F, Landig C, Siddiqui S, Secundino I, Garcia-Bingman A, Olson J, Varki N, Nizet V, Varki A. Paired Siglec receptors generate opposite inflammatory responses to a human-specific pathogen. EMBO J. 2017; 36:751-760. ABSTRACT  |  PDF
Storisteanu DM, Pocock JM, Cowburn AS, Juss JK Nadesalingam A, Nizet V, Chilvers ER. Evasion of neutrophil extracellular traps by respiratory pathogens. Am J Respir Cell Mol Biol 2017; 56:423-431. ABSTRACT  |  PDF
AAC.jpg Caffrey AR, Timbrook T, Noh E, Sakoulas G, Opal SM, Nizet V, LaPlante KL. Evidence to support continuation of statin therapy in patients with Staphylococcus aureus bacteremia. Antimicrob Agents Chemother 2017; 61:e02228-16. ABSTRACT  |  PDF   |  Supplemental
De Oliveira DM, Hartley-Tassel L, Everest-Dass A, Day CJ, Dabbs R, Nizet V, Packer NH, Walker MJ, Jennings MP, Sanderson-Smith ML. Blood group antigen recognition via the group A streptococcal M protein mediates host colonisation. mBio 2017; 8:e02237-16. ABSTRACT  |  PDF.
van Wijk XM, Döhrmann S, Voldborg BG, Hallström BM, Li S, Meng BX, McKee KK, van Kuppevelt TH, Yurchenco PD, Palsson BO, Lewis NE, Nizet V, Esko JD. Whole genome sequencing of invasion-resistant cells identifies laminin α2 as a host factor for bacterial invasion. mBio 2017; e02128-16. ABSTRACT  |  PDF.
AAC.jpg Sakoulas G, Rose W, Berti A, Olson J, Munguia J, Nonejuie P, Sakoulas E, Rybak MJ, Pogliano J, Nizet V. Classical β-lactamase inhibitors potentiate the activity of daptomycin against methicillin-resistant Staphylococcus aureus and colistin against Acinetobacter baumannii. Antimicrob Agents Chemother 2017; 61: e01745-16. ABSTRACT  |  PDF
Coady A, Nizet V. SAMP-ening down sepsis. Ann Transl Med 2016; 4:509. ABSTRACT  |  PDF
Askarian F, Uchiyama S, van Sorge NM, Sollid JU, Nizet V, van Strijp JA, Johannessen M. Serine-aspartate-repeat protein D increases Staphylococcus aureus virulence and survival in blood. Infect Immun 2016; 1:e00559-16. ABSTRACT  |  Supplemental   |  PDF
PlosBiol.png Sorg RA, Lin L, van Doorn S, Sorg M, Olson J, Nizet V, Veening JW. Collective resistance in microbial communities by intracellular antibiotic deactivation. PLoS Biol 2016; 14:e2000631. ABSTRACT  |  PDF   |  Supplemental
Hentrich K, Löfling J, Pathak A, Nizet V, Varki A, Henriques-Normark B. Streptococcus pneumoniae senses a humanlike sialic acid profile via the response regulator CiaR. Cell Host Microbe 2016; 20:307-17. ABSTRACT  |  PDF.
Buffalo CZ, Bahn-Suh AJ, Hirakis SP, Biswas T, Amaro RE, Nizet V, Ghosh P. Broad recognition in the interaction of group A Streptococcus M protein hypervariable regions with human C4b-binding protein. Nat Microbiol 2016; 1:16155. ABSTRACT  |  PDF   |  Supplemental
Flores R, Döhrmann S, Hakkim A, Nizet V, Corriden R. The selective estrogen receptor modulator raloxifene inhibits neutrophil extracellular trap formation. Front Immunol 2016; 7:566. ABSTRACT  |  PDF
AAC.jpg Sakoulas G, Olson J, Yim J, Singh N, Kumaraswamy M, Quach D, Rybak M, Pogliano J, Nizet V. Cefazolin and ertapenem: A synergistic combination used to clear persistent Staphylococcus aureus bacteremia. Antimicrob Agents Chemother 2016; 60:6609-6618. ABSTRACT  |  PDF
LaRock CN, Todd J, LaRock D, Olson J, Robertson AA, Cooper MA, Hoffman HM, Nizet V. IL-1β is an innate immune sensor of microbial proteolysis. Science Immunol 2016; 1:eaah3539. ABSTRACT  |  PDF    |  Supplemental   |  Commentary
Sganappa A, Bellucci MC, Nizet V, Tor Y, Volonterio A. Multicomponent domino synthesis and antibacterial activity of neomycin-sugar conjugates. Synthesis 2016; 48: 4443-4450. DOI: 10.1055/s-0035-1562727 ABSTRACT  |  PDF   |  Supplemental
PlosPath.png Döhrmann S, Cole JN, Nizet V. Conquering neutrophils. PLoS Pathog 2016; 12:e1005682. ABSTRACT  |  PDF
Makoni M, Eckert J, Pereira HA, Nizet V, Lawrence SM. Alterations in neutrophil function attributable to increased immature forms. Early Hum Dev 2016; 103:1-7.c ABSTRACT  |  PDF
Stewart C, Valderamma JA, Henningham A, Cole JN, Nizet V, Ghosh P. Coiled-coil destabilizing residues in the group A Streptococcus M1 protein are required for functional interaction. Proc Natl Acad Sci 2016; 13:9515-20. ABSTRACT  |  PDF   |  Supplemental
Rivera-Hernandez T, Pandey M, Henningham A, Cole JN, Choudhury B, Walker A, Duplanic C, Abdul Ghaffar K, West NP, Silvestri G, Good M, Moyle P, Toth I, Nizet V, Batzloff M, Walker MJ. Differing efficacy of lead group A streptococcal vaccine candidates and full-length M protein in cutaneous and invasive disease models. mBio 2016; 7:e00618-16. ABSTRACT  |  PDF.
Carey AJ, Weinberg JB, Dawid SR, Venturini C, Lam AK, Nizet V, Caparon M, Walker MJ, Watson ME, Ulett GC. Interleukin-17A controls Streptococcus pyogenes colonization and inflammation of the female genital tract. Sci Rep 2016; 6:26836. ABSTRACT  |  PDF.
Yamaguchi M, Hirose Y, Nakata M, Uchiyama S, Yamaguchi Y, Goto K, Sumitomo T, Lewis AL, Kawabata S, Nizet V. Evolutionary inactivation of a sialidase in group B Streptococcus. Sci Rep 2016; 6: 28852. ABSTRACT  |  PDF   |  Supplemental
Bosil E, Monk J, Aziz RK, Fondi M, Nizet V, Palsson BO. Comparative genome-scale modeling of multiple Staphylococcus aureus strains identifies unique metabolic capabilities linked to pathogenicity. Proc Natl Acad Sci USA 2016; 13:E3801-9. ABSTRACT  |  PDF
Eur-J-Clin-Micro.png Le J, Dam Q, Schweizer M, Thienphrapa W, Nizet V, Sakoulas G. Effects of vancomycin versus nafcillin in enhancing killing of methicillin-susceptible Staphylococcus aureus bacteremia by human cathelicidin LL-37. Eur J Clin Microbiol Infect Dis 2016; 35:1441-1447. ABSTRACT  |  PDF.
Hollands A, Corriden R, Gysler G, Dahesh S, Olson J, Kunkel MT, Lin AE, Forli S, Newton AC, Kumar GB, Nair BG, Perry JJP, Nizet V. Natural product anacardic acid from cashew nut shells stimulates neutrophil extracellular trap production and bactericidal activity. J Biol Chem 2016; 291:13964-13973. ABSTRACT  |  PDF.
AAC.jpg Lin L, Kim J, Chen H, Nizet V. Component analysis of multi-purpose contact lens solutions to enhance activity against Pseudomonas aeruginosa and Staphylococcus aureus. Antimicrob Agents Chemother 2016; 60:4259-4263. ABSTRACT     |  Supplemental   |  PDF
Huang YM, Miao Y, Munguia J, Lin L, Nizet V, McCammon JA. Molecular dynamic study of MlaC protein in Gram negative bacteria: conformational flexibility, solvent effect and protein-phospholipid binding. Prot Sci 2016; 25:1430-7. ABSTRACT  |  PDF
Völlger L, Akong-Moore KA, Cox L, Goldmann O, Wang Y, Schäfer S, Naim H, Nizet V, von Köckritz-Blickwede M. Iron chelating agent desferrioxamine stimulates formation of neutrophil extracellular traps (NETs) in human bloodderived neutrophils. Biosci Rep 2016; 36:e00333. ABSTRACT  |  PDF
von Köckritz-Blickwede M, Blodkamp S, Nizet V. Interaction of bacterial exotoxins with neutrophil extracellular traps: impact for the infected host. Front Microbiol 2016; 7:402. ABSTRACT  |  PDF
JAC.jpg Kumaraswamy M, Lin L, Olson J, Sun C-F, Nonejuie P, Corriden R, Döhrmann S, Ali SR, Amara D, Rohde M, Pogliano J, Sakoulas G, Nizet V. Standard susceptibility testing masks potent azithromycin activity and cationic peptide synergy against multidrug-resistant Stenotrophomonas maltophilia. J Antimicrob Chemother 2016; 71:1264-9. ABSTRACT  |  PDF  |  Supplemental
Quach DT, Sakoulas G, Nizet V, Pogliano J, Pogliano K. Bacterial cytological profiling as a rapid and accurate antimicrobial susceptibility testing method for Staphylococcus aureus. eBiomedicine 2016; 4: 95-103. ABSTRACT  |  PDF.
Microbiol-Spectr.jfif Cole JN, Nizet V. Bacterial evasion of host antimicrobial peptide defenses. Microbiol Spectr 2016; 4:VMBF-0006-2015. ABSTRACT  |  PDF.
AAC.jpg Berti AD, Theisen E, Demain-Sauer J, Nonejuie N, Olson J, Pogliano J, Sakoulas G, Nizet V, Proctor RA, Rose WE. Penicillin binding protein 1 is important in the compensatory response of Staphylococcus aureus to daptomycin-induced membrane damage and is a potential target for β-lactam-daptomycin synergy. Antimicrob Agents Chemother 2016; 60:451-458. ABSTRACT  |  PDF
Kolar S, Kyme P, Tseng CW, Soliman A, Kaplan A, Liangó J, Nizet V, Jiang D, Murali R, Arditi M, Underhill DM, Liu GY. Group B Streptococcus evades host immunity by degrading hyaluronan. Cell Host Microbe 2015; 18:694- 704. ABSTRACT  |  PDF
Uchiyama S, Döhrmann S, Timmer AM, Dixit N, Ghochani M, Bhandari T, Timmer JC, Sprague K, Bubeck-Wardenburg J, Simon SI, Nizet V. Streptolysin O rapidly impairs neutrophil oxidative burst and antibacterial responses to group A Streptococcus. Front Immunol 2015; 6:581. ABSTRACT  |  PDF  |  Supplemental.
LaRock CN, Nizet V. Inflammasome/IL-1β responses to streptococcal pathogens. Front Immunol 2015; 6:518. ABSTRACT  |  PDF.
EMBO.png Fong JJ, Sreehara K, Deng L, Varki NM, Angata T, Liu Q, Nizet V, Varki A. Immunomodulatory activity of extracellular Hsp70 mediated via paired receptors Siglec-5 and Siglec-14. EMBO J 2015; 34:2775-88. ABSTRACT  |  PDF  
Barnett T, Cole JN, Rivera Hernandez T, Henningham A, Paton J, Nizet V, Walker MJ. Streptococcal toxins: role in pathogenesis and disease. Cell Microbiol 2015; 17:1721-1741. ABSTRACT  |  PDF
LaRock CN, Döhrmann S, Todd J, Corriden R, Olson J, Johannssen T, Lepenies B, Gallo RL, Ghosh P, Nizet V. Group A streptococcal M1 protein sequesters cathelicidin to evade immune killing. Cell Host Microbe 2015; 18:471-477. ABSTRACT  |  PDF  |  Commentary
JCB.png Grimsey NJ, Aguilar B, Smith TH, Le PN, Soohoo A, Puthenveedu MA, Nizet V, Trejo J. Ubiquitin plays an atypical role in GPCR-induced p38 MAP kinase activation on endosomes. J Cell Biol 2015; 210:1117-1131. ABSTRACT  |  PDF.
Secundino I, Roupé KM, Wang X, Ali SR, Dahesh S, Amayreh LK, Varki A, Nizet V. Host and pathogen hyaluronan signal through human Siglec-9 to suppress neutrophil activation. J Mol Med 2015; 4:219-33. ABSTRACT  |  PDF.
Pence MA, Haste NM, Sabhatu HM, Olson J, Gallo RL, Nizet V, Kristian SA. Beta-lactamase repressor BlaI modulates Staphylococcus aureus cathelicidin antimicrobial peptide resistance and virulence. PLoS One 2015; 10:e0136605 ABSTRACT  |  PDF
Xu D, Olson J, Cole JN, van Wijk XM, Brinkmann V, Zychlinsky A, Nizet V, Esko JD, Chang YC. Heparan sulfate modulates neutrophil and endothelial function in antibacterial innate immunity. Infect Immun 2015; 83:3648-3656. ABSTRACT  |  PDF
AAC.jpg Sakoulas G, Kumaraswamy M, Nonejuie P, Werth B, Rybak MJ, Pogliano J, Rice LB, Nizet V. Differential effects of penicillin-binding protein inactivation on the susceptibility of Enterococcus faecium to cationic peptide antibiotics. Antimicrob Agents Chemother 2015; 59:6132-9. ABSTRACT  |  PDF.
Corriden R, Hollands A, Olson J, Derieux J, Lopez JM, Gonzalez DJ, Nizet V. Tamoxifen augments the innate immune function of neutrophils through modulation of intracellular ceramide. Nat Commun 2015; 6:8369. ABSTRACT  |  PDF  |  Supplemental.
Holden JK, Kang S, Beasley FC, Cinelli MA, Li H, Dejam D, Nizet V, Silverman RB, Poulos TL. Nitric oxide synthase as a target for methicillin-resistant Staphylococcus aureus. Chem Biol 2015; 22:785-92. ABSTRACT  |  PDF.
Lin L, Nonejuie P, Munguia J, Hollands A, Olson J, Dam Q, Kumaraswamy M, Rivera H, Corriden R, Rohde M, Hensler ME, Burkart MD, Pogliano J, Sakoulas G, Nizet V. Azithromycin synergizes with cationic antimicrobial peptides to exert bactericidal and therapeutic activity against highly multidrug-resistant Gram-negative bacterial pathogens. eBiomedicine 2015; 2:690–698. ABSTRACT  |  PDF  |  Supplemental  |  Commentary
AAC.jpg Hindler J, Wong-Beringer A, Charlton C, Campeau Miller S, Kelesidis T, Carvalho M, Sakoulas G, Nonejuie P, Pogliano J, Nizet V, Humphries R. In vitro activity of daptomycin in combination with β-lactams, gentamicin, rifampin and tigecycline against daptomycin non-susceptible enterococci. Antimicrob Agents Chemother 2015; 59:4279-8. ABSTRACT  |  PDF
Nizet V. Stopping superbugs, maintaining the microbiota. Sci Transl Med. 2015; 7:295ed8. ABSTRACT  |  PDF
Kristian SA, Hwang JH, Hall B, Liere E, Iacomini J, Old R, Galili U, Roberts C, Mullis KB, Westby M, Nizet V. Retargeting preexisting human antibodies to a bacterial pathogen with an alpha-Gal conjugated aptamer. J Mol Med 2015; 93:619-31. ABSTRACT  |  PDF  |  Supplemental  |  Commentary   |  Press Release
Awakawa T, Crüsemann M, Munguia J, Ziemer N, Nizet V, Moore BS. Salinipyrone and pacificanone are biosynthetic byproducts of the rosamicin polyketide synthase. ChemBioChem 2015; 16:1443-7. ABSTRACT  |  PDF  |  Supplemental
McEachern EK, Hwang JH, Sladewski KM, Nicatia S, Dewitz C, Mathew D, Nizet V, Crotty Alexander LE. Analysis of the effects of cigarette smoke on staphylococcal virulence phenotypes. Infect Immun 2015; 83:2443-52. ABSTRACT  |  PDF  |  Supplemental.
PlosPath.png Lin AE, Beasley FC, Olson J, Keller N, Shalwitz RA, Hannan TJ, Hultgren SJ, Nizet V. Role of hypoxia inducible factor-1α (HIF-1α) in innate defense against uropathogenic Escherichia coli infection. PLoS Pathogens 2015; 11:e1004818. ABSTRACT  |  PDF  |  Supplemental
Harbut MB, Vilcheze C, Luo X, Hensler ME, Guo H, Yang B, Chatterjee AK, Nizet V, Jacobs WR, Shultz PG, Wang F. Auranofin exerts broad-spectrum bactericidal activities by targeting thiol-redox homeostasis. Proc Natl Acad Sci USA 2015; 112:4453-8. ABSTRACT   |  Supplemental  |  PDF
Lin AE, Beasley FC, Keller N, Hollands A, Urbano R, Troemel ER, Hoffman HM, Nizet V. Group A Streptococcus ADP-ribosyltransferase toxin SpyA stimulates a protective IL-1β-dependent macrophage immune response. mBio 2015; 6:e00133-15. ABSTRACT  |  PDF  |  Supplemental
Shalova IN, Lim JY, Chittezhath M, Zinkernagel AS, Beasley F, Hernández-Jiménez E, Toledano V, Rapsardi A, Chen J, Kaibo D, Yang H, Poidinger M, Melillo G, Nizet V, Arnalich F, Lopez-Collazo E, Biswas SK. Human monocytes undergo functional re-programming during sepsis mediated by hypoxia-inducible factor-1α. Immunity 2015;
42:484-98. ABSTRACT  |  PDF  
AAC.jpg Berti AD, Baines SL, Howden BP, Sakoulas G, Nizet V, Proctor RA, Rose WE. Heterogeneity of genetic pathways toward daptomycin nonsusceptibility in Staphylococcus aureus determined by adjunctive antibiotics. Antimicrob Agents Chemother 2015; 59:2799 –806. ABSTRACT  |  PDF
BiochemBiophys-Acta.png LaRock CN, Nizet V. Cationic antimicrobial peptide resistance mechanisms of streptococcal pathogens. Biochim Biophys Acta 2015; 1848:3047-54. ABSTRACT  |  PDF
AAC.jpg Sakoulas G, Nonejuie P, Kullar R, Pogliano J, Rybak MJ, Nizet V. Examining the use of ceftaroline in the treatment of Streptococcus pneumoniae meningitis with reference to human cathelicidin LL-37. Antimicrob Agents Chemother 2015; 59:2428-31. ABSTRACT  |  PDF
Matak P, Heinis M, Mathieu JR, Corriden R, Delga S, Rouquette A, Mounier R, Raymond J, Lamarque D, Emile JF, Nizet V. Touati E, Peyssonnaux C. Myeloid HIF-1 is protective in H. pylori-mediated gastritis. J Immunol 2015; 194:3259-66. (cover article) ABSTRACT  |  PDF  |  Supplemental
Bier E, Nizet V. Hedgehog: Linking uracil to innate defense. Cell Host Microbe 2015; 17:146-158. ABSTRACT  |  PDF
FEMS.png Henningham A, Döhrmann S, Nizet V, Cole JN. Mechanisms of group A Streptococcus resistance to reactive oxygen species. FEMS Microbiol Rev 2015; 39:488-508. ABSTRACT  |  PDF
Ali SR, Karin M, Nizet V. Signaling cascades and inflammasome activation in microbial infections. Inflammasome 2015; 2:7–12. DOI:10.1515/infl-2015-0002 ABSTRACT  |  PDF
Patel V, Carrion K, Hollands A, Hinton A, Gallegos T, Dyo J, Sasik R, Leire E, Hardiman G, Mohamed SA, Nigam S, King CC, Nizet V, Nigam V. The stretch responsive microRNA miR-148a is a novel repressor of IκBkB, NF-κB signaling, and inflammatory gene expression in human aortic valve cells. FASEB J 2015; 29:1859-68. ABSTRACT  |  PDF  |  Supplemental
Wilkinson DS, Shah J, Ericka Anderson EL, Mitra K, Meisenhelder J, Chang JT, Ideker T, Hunter T, Nizet V, Dillin A, Hansen M. Phosphorylation of LC3 by the sterile-20 kinases STK3/STK4 is essential for autophagy. Mol Cell 2015; 57:55-68. ABSTRACT  |  PDF
Gonzalez DJ, Corriden R, Akong-Moore K, Olson J, Dorrestein PC, Nizet V. N-terminal ArgD peptides from the classical Staphylococcus aureus Agr system have cytotoxic and proinflammatory activities. Chem Biol 2014; 21:1457-1462. ABSTRACT  |  PDF
Kang S, Watanabe M, Jacobs JC, Yamaguchi M, Dahesh S, Nizet V, Leyh TS, Silverman RB. Synthesis of mevalonate and fluorinated mevalonate prodrugs and their in vitro human plasma stability. Eur J Med Chem 2014; 90C:448-461. ABSTRACT  |  PDF
Henningham A, Yamaguchi M, Aziz RK, Kuipers K, Buffalo CZ, Dahesh S, Choudhury B, Van Vleet J, Yamaguchi Y, Seymour LM, Ben Zakour NL, He L, Smith HV, Grimwood K, Beatson SA, Ghosh P, Walker MJ, Nizet V, Cole JN. Mutual exclusivity of hyaluronan and hyaluronidase in invasive group A Streptococcus. J Biol Chem 2014; 289:32303-32315. ABSTRACT  |  PDF
Palazon A, Goldrath A, Nizet V, Johnson RS. HIF transcription factors, inflammation and immunity. Immunity 2014; 41:518-528. ABSTRACT  |  PDF
Neumann A, Völlger L, Berends ET, Nerlich A, Molhoek EM, Gallo RL, Meerloo T, Nizet V, Naim HY, von Köckritz-Blickwede M. The antimicrobial peptide LL-37 facilitates the formation of neutrophil extracellular traps. Biochem J 2014; 2014; 464:3–11. ABSTRACT  |  PDF
Vega VL, Crotty Alexander LE, Charles W, Nizet V, De Maio A. Activation of the stress response in macrophages alters the M1/M2 balance by enhancing bacterial killing and increasing IL-10 expression. J Mol Med 014; 92:1305-1317. ABSTRACT  |  PDF
Schommer NN, Muto J, Nizet V, Gallo RL. Hyaluronan breakdown contributes to immune defense against group A Streptococcus. J Biol Chem 2014; 289:26914-21. ABSTRACT  |  PDF
Döhrmann S, Anik S, Olson J, Anderson EL, Etesami N, No H, Snipper J, Nizet V, Okumura CY. A role for streptococcal collagen-like protein-1 (Scl-1) in M1T1 group A Streptococcus resistance to neutrophil extracellular traps. Infect Immun 2014; 82:4011-20. ABSTRACT  |  PDF  |  Supplemental
Guichard A, Nizet V, Bier E. Rab11-mediated trafficking in host-pathogen interactions. Nat Rev Microbiol 2014; 12:624-34. ABSTRACT  |  PDF
Chang YC, Nizet V. The interplay between Siglecs and sialylated pathogens. Glycobiology 2014; 24: 818-25. ABSTRACT  |  PDF
Fair RJ, McCoy LS, Hensler ME, Aguilar B, Nizet V, Tor Y. Singly modified amikacin and tobramycin derivatives show increased rRNA A-site binding and higher potency against resistant bacteria. ChemMedChem 2014; 9:2164-71. ABSTRACT  |  PDF
Sakoulas G, Moise PA, Casapao AM, Nonejuie P, Olson J, Okumura CY, Rybak MJ, Kullar R, Dhand A, Rose WE, Goff DA, Bressler AM, Lee Y, Pogliano J, Johns S, Kaatz GW, Ebright JR, Nizet V. Antimicrobial salvage therapy for persistent staphylococcal bacteremia using daptomycin plus ceftaroline. Clin Therap 2014; 36:1317-1333. ABSTRACT  |  PDF
Neumann A, Völlger L, Berends ET, Molhoek EM, Stapels DA, Midon M, Friães A, Pingoud A, Rooijakkers SM, Gallo RL, Mörgelin M, Nizet V, Naim HY, von Köckritz-Blickwede M. Novel role of the antimicrobial peptide LL-37 in the protection of neutrophil extracellular traps against degradation by bacterial nucleases. J Innate Immun 2014; 6:860-868. ABSTRACT  |  PDF.
Bhandari T, Nizet V. HIF as a pharmacological target for prevention and treatment of infectious diseases. Infect Dis Ther 2014; 3:159-74. ABSTRACT  |  PDF
Ann-Rev-Micro.png Okumura CYM, Nizet V. Subterfuge and sabotage: Evasion of host innate defenses by invasive Gram-positive bacterial pathogens. Ann Rev Microbiol 2014; 68:439-58. ABSTRACT  |  PDF
van Sorge NM, Cole JN, Kuipers K, Henningham A, Aziz RK, Kasirer-Friede A, Lin L, Berends ETM, Davies MR, Dougan G, Zhang F, Dahesh S, Shaw L, Gin J, Cunningham M, Merriman JA, Hütter J, Lepenies B, Rooijakkers SHM, Malley R, Walker MJ, Shattil SJ, Schlievert PM, Choudhury B, Nizet V. The classical Lancefield antigen of group A Streptococcus is a virulence determinant with implications for vaccine design. Cell Host Microbe 2014; 15:729-40. ABSTRACT  |  PDF.
Chang YC, Olson J, Louie A, Crocker PR, Varki A, Nizet V. Role of macrophage sialoadhesin in host defense against the sialylated pathogen group B Streptococcus. J Mol Med 2014; 92:951-9. ABSTRACT  |  PDF  |  Supplemental
Sakoulas G, Guram K, Reyes K, Nizet V, Zervos M. Human cathelicidin LL-37 resistance and daptomycin MIC creep in USA600 (ST45) methicillin-resistant Staphylococcus aureus associated with increased mortality in a hospital setting. J Clin Microbiol 2014; 52:2172-4. ABSTRACT  |  PDF  |  Supplemental
Tagliabraccia VS, Engel JL, Wiley SE, Xiao J, Gonzalez DJ, Nidumanda Appaiah H, Nizet V, White KE, Dixon JE. Dynamic regulation of FGF23 by FAM20C phosphorylation, GALNT3 glycosylation and Furin proteolysis. Proc Natl Acad Sci USA 2014; 111:5520-5. ABSTRACT  |  PDF
JEM.png Ali SR, Fong J, Carlin AF, Busch TD, Linden R, Angata T, Areschoug T, Parast M, Varki N, Murray J, Nizet V, Varki A. Siglec-5 and -14 are polymorphic paired receptors that modulate neutrophil and amnion signaling responses to group B Streptococcus. J Exp Med 2014; 211:1231-42. ABSTRACT  |  PDF
Mol-Cell-Proteomics.png Gonzalez DJ, Vuong L, Gonzalez IS, Hwang HK, Hung J, Dixon JE, Dorrestein PC, Nizet V. Phenol soluble modulin variants of community-associated methicillin-resistant Staphylococcus aureus captured using mass spectrometry-based molecular networking. Mol Cell Proteomics 2014; 13:1262-72. ABSTRACT  |  PDF  |  Supplemental
Marine-drugs.png Liu Y, Haste NM, Thienphrapa W, Li J, Nizet V, Hensler M, Li R. Marinopyrrole derivatives as potential antibiotic agents against methicillin-resistant Staphylococcus aureus (III). Marine Drugs 2014; 12:2458-70. ABSTRACT  |  PDF
Hensler ME, Haste NM, Jang KH, Thienphrapa W, Vuong L, Tran DN, Soubih E, Lin L, Cunningham ML, Kwan B, Shaw KJ, Fenical W, Nizet V. Anthracimycin activity against contemporary methicillin-resistant Staphylococcus aureus. J Antibiot 2014; 67:549-53. ABSTRACT  |  PDF
Walker MJ, Barnett TC, McArthur JD, Cole JN, Gillen CM, Henningham A, Sriprakash KS, Sanderson-Smith ML, Nizet V. Disease manifestations and pathogenic mechanisms of group A Streptococcus. Clin Microbol Rev 2014; 27:264-301. ABSTRACT  |  PDF
Franks SE, Ebrahimi C, Hollands A, Okumura CY, Aroian RV, Nizet V, McGillivray SM. Novel role for the yceGH tellurite resistance genes in the pathogenesis of Bacillus anthracis. Infect Immun 2014; 82:1132-40. ABSTRACT  |  PDF
Randis TM, Gelber SE, Hooven TA, Abellar RG, Akabas LH, Lewis EL, Walker LB, Byland LM, Nizet V, Ratner AJ. Group B Streptococcus β-hemolysin/cytolysin breaches maternal-fetal barriers to cause preterm birth and intrauterine fetal demise in vivo. J Infect Dis 2014; 210:265-73. ABSTRACT  |  PDF
Askarian F, van Sorge NM, Sangvika M, Beasley FC, Henriksend JR, Sollida JU, van Strijp J, Nizet V, Johannessen M. Α Staphylococcus aureus TIR domain protein virulence factor blocks TLR2-mediated NF-κB signaling. J Innate Immun 2014; 6:485-98. ABSTRACT  |  PDF  |  Supplemental
Padler-Karavani V, Hurtado-Ziola N, Chang YC, Sonnenburg JL, Ronaghy A, Yu H, Verhagen A, Nizet V, Chen X, Varki N, Varki A, Angata T. Rapid evolution of binding specificities and expression patterns of inhibitory CD33-related Siglecs in primates. FASEB J 2014; 28:1280-93. ABSTRACT  |  PDF
Ly D, Taylor JM, Tsatsaronis J, Monteleone M, Skora A, Donald C, Maddocks T, Nizet V, West N, Ranson M, Walker M, McArthur J, Sanderson-Smith M. Plasmin(ogen) acquisition by group A Streptococcus protects against C3b mediated neutrophil killing. J Innate Immun 2014; 6: 240-50. ABSTRACT  |  PDF
Opaluch AM, Schneider M, Chiang CY, Nguyen QT, Maestre AM, Mulder LC, Secundino I, De Jesus PD, König R, Simon V, Nizet V, MacLeod G, Varmuza S, Fernandez-Sesma A, Chanda SK. Positive regulation of TRAF6-dependent innate immune responses by protein phosphatase PP1-γ. PLoS One 2014 9:e89284. ABSTRACT    |  Supplemental  |  PDF
Anderson EL, Cole JN, Olson J, Ryba B, Ghosh P, Nizet V. The fibrinogen-binding M1 protein reduces pharyngeal cell adherence and colonization phenotypes of M1T1 group A Streptococcus. J Biol Chem 2014; 289:3539–46. ABSTRACT  |  PDF
AAC.jpg Sakoulas G, Rose W, Nonjuie P, Olson J, Pogliano J, Humphries R, Nizet V. Ceftaroline restores daptomycin activity against daptomycin-nonsusceptible vancomycin-resistant Enterococcus faecium. Antimicrob Agents Chemother 2014; 58:1494- 500. ABSTRACT  |  PDF  |  Supplemental
Roupé KM, Veerla S, Olson J, Stone EL, Sørensen O, Hedrick SM, Nizet V. Transcription factor binding site analysis identifies FOXO transcription factors as regulators of the cutaneous wound healing process. PLoS One 2014; 9: e89274. ABSTRACT  |  PDF  |  Supplemental
Cowburn AS, Crotty Alexander LE, Nizet V, Chilvers ER, Johnson RS. Epidermal deletion of HIF-2α stimulates wound closure. J Invest Derm 2014; 134: 801–8. ABSTRACT  |  PDF  |  Supplemental
Yamanaka K, Reynolds KA, Kersten RD, Ryan KS, Gonzalez DJ, Nizet V, Dorrestein PC, Moore BS. Direct cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the antibiotic taromycin A. Proc Natl Acad Sci USA 2014; 111:1957-62. ABSTRACT  |  PDF  |  Supplemental
Sakoulas G, Okumura CY, Thienphrapa W, Olson J, Dam Q, Dhand A, Yeaman MR, Hensler ME, Bayer AS, Nizet V. Nafcillin enhances innate immune-mediated killing of methicillin-resistant Staphylococcus aureus. J Mol Med 2014; 92:139-49. ABSTRACT    |  PDF  |  Commentary
PlosPath.png Chang YC, Olson J, Beasley FC, Tung C, Zhang J, Crocker PR, Varki A, Nizet V. Group B Streptococcus engages an inhibitory Siglec through sialic acid mimicry to blunt innate immune and inflammatory responses in vivo. PLoS Pathogens 2014; 10:e1003846. ABSTRACT  |  PDF  |  Supplemental
Lin AE, Autran CA, Española SD, Bode L, Nizet V. Human milk oligosaccharides protect bladder epithelial cells against uropathogenic Escherichia coli invasion and cytotoxicity. J Infect Dis 2014; 209:389-98. ABSTRACT  |  PDF  |  Supplemental  |  Commentary
Crotty Alexander L, Marsh B, Timmer A, Zainabadi K, Czopik A, Guarente L, Nizet V. Myeloid cell sirtuin-1 expression does not alter host immune responses to Gram-negative endotoxemia or Gram-positive bacterial infection. PLoS One 2013; 8:e84481. ABSTRACT  |  PDF  |  Supplemental
Barnett TC, Liebl D, Seymour LM, Gillen CM, Lim JY, LaRock CN, Davies MR, Shulz BL, Nizet V, Teasdale RD, Walker MJ. The globally disseminated M1T1 clone of group A Streptococcus evades autophagy for intracellular replication. Cell Host Microbe 2013; 14:675-82. ABSTRACT  |  PDF  |  Supplemental   |  Commentary  |  Cover Article
Grewal PK, Aziz PV, Uchiyama S, Rubio GR, Le D, Varki N, Nizet V, Marth JD. Inducing host protection in pneumococcal sepsis by preactivation of the Ashwell-Morell receptor. Proc Natl Acad Sci USA 2013; 110:20218-23. ABSTRACT  |  PDF  |  Supplemental
Kersten RD, Ziemert N, Gonzalez DJ, Duggan BM, Nizet V, Dorrestein PC, Moore BS. Glycogenomics as a mass spectrometry guided genome-mining method for microbial glycosylated molecules. Proc Natl Acad Sci USA 2013; 110:E4407-16. ABSTRACT  |  PDF  |  Supplemental
Cowburn A, Takeda N, Boutin AT, Kim J-W, Sterling JC, Nakasaki M, Southwood M, Goldrath AW, Jamora C, Nizet V, Chilvers ER, Johnson RS. HIF isoforms in the skin differentially regulate systemic arterial pressure. Proc Natl Acad Sci USA 2013; 110:17570-5. ABSTRACT  |  PDF  |  Supplemental
Yamaguchi M, Terao Y, Mori-Yamaguchi Y, Domon H, Sakaue Y, Yagi T, Nishino K, Yamaguchi A, Nizet V, Kawabata S. Streptococcus pneumoniae invades erythrocytes and utilizes them to evade human innate immunity. PLoS One 2013; 8:e77282. PMID: 24194877 ABSTRACT  |  PDF
Fine AM, Nizet V, Mandl KD. Participatory medicine: A home score for streptococcal pharyngitis enabled by real- time biosurveillance: a cohort study. Ann Intern Med 2013; 159:577-83. ABSTRACT  |  PDF  |  Commentary  |  Commentary
Guichard A, Cruz-Moreno B, Aguilar B, van Sorge NM, Kuang J, Kurkciyan AA, Wang Z, Hang S, Pineton de Chambrun GP, McCole DF, Watnick P, Nizet V, Bier E. Cholera toxin disrupts barrier function by inhibiting exocystmediated trafficking of host proteins to intestinal cell junctions. Cell Host Microbe 2013; 14:294-305. ABSTRACT  |  PDF  |  Supplemental  |  Commentary
Nizet V, Yaksh T. Neuroscience: Bacteria get on your nerves. Nature 2013; 501:43-4. ABSTRACT  |  PDF
Leire E, Olson J, Isaacs H, Nizet V, Hollands A. Role of hypoxia inducible factor-1 in keratinocyte inflammatory response and neutrophil recruitment. J Inflamm 2013; 10:28. ABSTRACT  |  PDF
Sjögren J, Struwe W, Cosgrave E, Rudd P, Stervander M, Allhorn M, Hollands A, Nizet V, Collin M. EndoS2 is a unique and conserved protein of serotype M49 group A Streptococcus that hydrolyzes N-linked glycans on IgG and α1-acid glycoprotein. Biochem J 2013; 455:107-118. ABSTRACT  |  PDF  |  Supplemental
Okumura CY, Anderson EL, Döhrmann S, Tran DN, Olson J, von Pawel-Rammingen U, Nizet V. IgG protease Mac/IdeS is not essential for phagocyte resistance or mouse virulence of M1T1 group A Streptococcus. mBio 2013; 4:3e0049-13. ABSTRACT  |  PDF
AAC.jpg Berti AE, Sakoulas G, Nizet V, Rose WE. β-lactam antibiotics targeting PBP1 selectively enhance daptomycin activity against methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother 2013; 57:5005-12. ABSTRACT  |  PDF
EMBO.png Corriden R, Self T, Akong-Moore K, Nizet V, Kellam B, Briddon S, Hill S. Human neutrophil A3-adenosine receptor microdomains promote bacteria-tethering cytoneme formation. EMBO Reports 2013; 14:726-32. ABSTRACT  |  PDF  |  Supplemental
PlosPath.png Sanderson-Smith ML, Zhang Y, Ly D, Donahue D, Hollands A, Nizet V, Ploplis VA, Walker MJ, Castellino FJ. A key role for the urokinase plasminogen activator (uPA) in invasive group A streptococcal infection. PLoS Pathogens 2013; 9:e1003469. ABSTRACT  |  PDF  |  Supplemental
Bhandari T, Olson J, Johnson RS, Nizet V. HIF-1α influences myeloid cell antigen presentation and response to subcutaneous OVA vaccination. J Mol Med 2013; 91:1199-205. ABSTRACT  |  PDF
AAC.jpg Sakoulas G, Nonejuie P, Nizet V, Pogliano J, Crum-Ciaflone N, Haddad F. Treatment of recurrent high-level gentamicin-resistant Enterococcus faecalis endocarditis with daptomycin plus ceftaroline. Antimicrob Agents Chemother 2013; 57:4042-5. ABSTRACT  |  PDF
Jantsch J, Gerlach R, Ensser A, Dahesh S, Popp I, Heeg C, Bleiziffer O, Merz T, Schulz T, Horch R, Bogdan C, Nizet V, Van Der Linden M. Severe soft tissue infection caused by a non-β-hemolytic Streptococcus pyogenes strain harboring a premature stop mutation in the sagC gene. J Clin Microbiol 2013; 51:1962–5. ABSTRACT  |  PDF
Venturini C, Ong CY, Gillen CM, Ben-Zakour N, Maamary PG, Nizet V, Beatson SA, Walker MJ. Acquisition of the Sda1-encoding bacteriophage does not enhance virulence of the serotype M1 Streptococcus pyogenes strain SF370. Infect Immun 2013; 81:2062-9. ABSTRACT  |  PDF
Tsatsaronis J, Hollands A, Cole JN, Maamary PG, McArthur JD, Ben Zakour N, Kotb M, Nizet V, Beatson S, Walker MJ, Sanderson-Smith ML. Streptococcal collagen-like protein A and general stress protein 24 are immuno-modulating virulence factors of group A Streptococcus. FASEB J 2013; 27:2633-43. ABSTRACT  |  PDF  |  Supplemental
Angata T, Ishii T, Motegi T, Oka R, Taylor RE, Campos-Soto P, Chang YC Secundino I, Gao CX, Ohtsubo K, Kitazumi S, Nizet V, Varki A, Gemma A, Kida K, Taniguchi N. Loss of Siglec-14 reduces the risk of chronic obstructive pulmonary disease exacerbation. Cell Mol Life Sci 2013; 70:3199-210. ABSTRACT  |  PDF
Uchiyama S, Andreoni F, Zürcher C, Schilcher K, Ender M, Madon J, Matt U, Ghosh P, Nizet V, Scheupbach RA, Zinkernagel AS. Coiled-coil irregularities of the M1 protein structure promote M1-fibrinogen interaction and influence group A Streptococcus host cell interactions and virulence. J Mol Med 2013; 91:861-9. ABSTRACT  |  PDF  |  Supplemental
Tannahill GM, Curtis AM, Adamik J, Palsson-McDermott EM, McGettrick AF, Goel G, Frezza C, Bernard NJ, Kelly B, Foley NH, Zheng L, Gardet A, Tong Z, Jany SS, Corr SC, Clish C, Haneklaus M, Caffrey BE, Pierce K, Walmsley S, Beasley FC, Cummins E, Nizet V, Whyte M, Taylor CT, Lin H, Masters SL, Gottlieb E, Kelly VP, Clish C, Auron PE, Xavier RJ, O’Neill LAJ. Succinate is an inflammatory signal that induces IL-1β transcription through HIF-1α. Nature 2013; 496:238-42. ABSTRACT  |  PDF  |  Supplemental
Baek KJ, Cho JY, Rosenthal P, Crotty Alexander LE, Nizet V, Broide DH. Hypoxia potentiates allergen induction of HIF-1α, chemokines, airway inflammation, TGF-β1, and airway remodeling in a mouse model. Clin Immunol 2013; 147:27-37. ABSTRACT  |  PDF
van Sorge NM, Beasley FC, Gusarov I, Gonzalez DJ, von Köckritz-Blickwede M, Anik S, Borkowski A, Dorrestein P, Nudler E, Nizet V. Methicillin-resistant Staphylococcus aureus bacterial nitric-oxide synthase affects antibiotic sensitivity and skin abscess development. J Biol Chem 2013; 288:6417-26. ABSTRACT  |  PDF  |  Supplemental
Zhu W, Zhang Y, Sinko W, Hensler ME, Molohon KJ, Lindert S, Cao R, Li K, Wang K, Wang Y, Liu YL, Sankovsky A, de Oliveira CA, Mitchell DA, Nizet V, McCammon JA, Oldfield E. Antibacterial drug leads targeting isoprenoid biosynthesis. Proc Natl Acad Sci USA 2013; 110:123-8. ABSTRACT  |  PDF
Crotty Alexander LE, Akong K, Feldstein S, Johansson P, Nguyen A, McEachern EK, Nicatia S, Cowburn AS, Olson J, Cho JY, Isaacs H, Johnson RS, Broide DH, Nizet V. Myeloid cell HIF-1α regulates asthma airway resistance and eosinophil function. J Mol Med 2013; 91:637-44. ABSTRACT  |  PDF
Hollands A, Gonzalez DJ, Leire E, Donald C, Gallo RL, Sanderson-Smith M, Dorrestein PC, Nizet V. A bacterial pathogens co-opts host plasmin to resist killing by cathelicidin antimicrobial peptides. J Biol Chem 2012; 287:40891- 7. ABSTRACT  |  PDF
Plos-Gen.png Kuang E, Okumura CY, Sheffy-Levin S, Varzano T, Shu VC, Qi J, Niesman IR, Olson J, Reed JC, Broday L, Nizet V, Ronai ZA. Regulation of ATG4B stability by RNF5 limits basal levels of autophagy and influences susceptibility to bacterial infection. PLoS Genetics 2012 2012; 8(10):e1003007. ABSTRACT  |  PDF
Haste NM, Thienphrapa W, Tran DN, Loesgen S, Sun P, Nam SJ, Jensen PR, Fenical W, Sakoulas G, Nizet V, Hensler ME. Activity of the thiopeptide antibiotic nosiheptide against contemporary strains of methicillin-resistant Staphylococcus aureus. J Antibiotics 2012; 65:593-8. ABSTRACT  |  PDF
Rose WE, Eickhoff JC, Shukla SK, Pantarangi M, Rooijakkers SH, Cosgrove SE, Nizet V, Sakoulas G. Elevated serum interleukin-10 (IL-10) at time of hospital admission is predictive of mortality in patients with Staphylococcus aureus bacteremia. J Infect Dis 2012; 206:1604-11. ABSTRACT  |  PDF  |  Supplemental
AAC.jpg Humphries RM, Kelesidis T, Tewhey R, Rose W, Schork N, Nizet V, Sakoulas G. Genotypic and phenotypic evaluation of the evolution of high-level daptomycin non-susceptibility in vancomycin-resistant Enterococcus faecium. Antimicrob Agents Chemother 2012; 56:6051-3. ABSTRACT  |  PDF
Cole JN, Aziz RK, Kuipers K, Timmer AM, Nizet V, van Sorge NM. A conserved UDP-glucose dehydrogenase outside the hasABC operon contributes to capsule biogenesis in group A Streptococcus. J Bacteriol 2012; 194:6154-61. ABSTRACT  |  PDF
Dahesh S, Nizet V, Cole JN. Study of streptococcal hemoprotein receptor (Shr) in iron acquisition and virulence of M1T1 group A Streptococcus. Virulence 2012; 3:566-75. ABSTRACT  |  PDF  |  Commentary
Maamary PG, Ben Zakour NL, Cole JN, Hollands A, Aziz RK, Barnett TC, Cork AJ, Henningham A, Sanderson-Smith M, McArthur JD, Venturini C, Gillen CM, Kirk JK, Johnson DR, Taylor WL, Kaplan EL, Kotb M, Nizet V, Beatson SA, Walker MJ. Tracing the evolutionary history of the pandemic group A streptococcal M1T1 clone. FASEB J 2012; 26:4675-84. ABSTRACT  |  PDF
Branitzki-Heinemann K, Okumura CY, Völlger L, Kawakami Y, Kawakami T, Naim HY, Nizet V, von Köckritz-Blickwede M. Novel role of the transcription factor HIF-1α in the formation of mast cell extracellular traps. Biochem J 2012; 446: 159-63. ABSTRACT  |  PDF
Akong-Moore K, Chow OA, von Köckritz-Blickwede M, Nizet V. Influences of chloride and hypochlorite on neutrophil extracellular trap formation. PLoS One 2012 7:e42984. ABSTRACT  |  PDF
PlosPath.png Bebien M, Hensler ME, Hsu LC, Karin M, Park JM, Alexopoulou L, Liu GY, Nizet V, Lawrence T. The pore- forming β-hemolysin/cytolysin of group B Streptococcus activates p38 MAPK-dependent IL-10 production in macrophages and inhibits innate immunity. PLoS Pathogens 2012; 8:e1002812. ABSTRACT  |  PDF
Gonzalez DJ, Xu Y, Yang YL, Esquenazi E, Liu WT, Edlund A, Duong D, Du L, Molnár I, Gerwick WH, Jensen PR, Fischbach M, Liaw CC, Straight P, Nizet V, Dorrestein PC. Observing the invisible through imaging mass spectrometry, a window into the metabolic exchange patterns of microbes. J Proteomics 2012; 287:13889-98. ABSTRACT  |  PDF  |  Supplemental
Wang X, Mitra N, Secundino-Velasquez I, Banda K, Cruz P, Padler-Karavani V, Verhagen A, Reid C, Lari M, Rizzi E, Balsamo C, Corti G, De Bellis G, Longo L, NISC Comparative Sequencing Program, Beggs W, Caramelli D, Tishkoff S, Hayakawa T, Green ED, Mulliken JC, Nizet V, Bui JD, Varki A. Specific inactivation of two immunomodulatory SIGLEC genes during human evolution. Proc Natl Acad Sci USA 2012 109:9935-40. ABSTRACT  |  PDF  |  Supplemental
PlosPath.png Uchiyama S, Andreoni F, Schüpbach RA, Nizet V, Zinkernagel AS. DNase Sda1 allows invasive M1T1 group A Streptococcus to escape TLR9 recognition. PLoS Pathogens 2012 8:e1002736. ABSTRACT  |  PDF  |  Supplemental
Fair RJ, Hensler ME, Thienphrapa W, Dam QN, Nizet V, Tor Y. Selectively guanidinylated aminoglycosides as antibiotics. ChemBioChem 2012; 7:1237-44. ABSTRACT  |  PDF  |  Supplemental
van der Westhuyzen R, Hammons J, Meier J, Dahesh S, Moolman W, Pelley S, Nizet V, Burkart M, Strauss E. The antibiotic CJ-15,801 is an antimetabolite which hijacks and then inhibits CoA biosynthesis. Chem Biol 2012; 19:559- 71 (Cover article). ABSTRACT  |  PDF  |  Commentary
Sano R, Hou YC, Hedvat M, Correa RG, Shu CW, Krajewska M, Diaz PW, Quarato G, Gottlieb RA, Yamaguchi M, Nizet V, Dahl R, Thomas DD, Tait SW, Green DR, Fisher PB, Matsuzawa SI, Reed JC. Endoplasmic reticulum protein BI-1 regulates Ca2+-mediated bioenergetics to promote autophagy. Genes Dev 2012; 26:1041-54. ABSTRACT  |  PDF  |  Supplemental
Marine-drugs.png Liu Y, Haste NM, Thienphrapa W, Nizet V, Hensler ME, Li R. Marinopyrrole derivatives as potential antibiotic agents against methicillin-resistant Staphylococcus aureus (I). Marine Drugs 2012; 10:953-962. ABSTRACT  |  PDF
Henningham A, Chiarot E, Gillen CM, Cole JN, Rohde M, Fulde M, Ramachandran V, Cork AJ, Hartas J, Magor G, Djordjevic SP, Cordwell SJ, Kobe B, Sriprakash KS, Nizet V, Chhatwal GS, Batzloff MR, Margarit IR, Walker MJ. Conserved anchorless surface proteins as group A streptococcal vaccine candidates. J Mol Med 2012; 90:1197- 1207.
ABSTRACT  |  PDF  |  Supplemental
Hertzén E, Johansson L, Kansal R, Hecht A, Dahesh S, Marton J, Nizet V, Kotb M, Norrby-Teglund. Intracellular Streptococcus pyogenes in human macrophages display an altered gene expression profile. PLoS One 2012; 7:e35218. ABSTRACT  |  PDF
Fine AM, Nizet V, Mandl KD. Large-scale validation of the Centor and McIsaac scores to predict group A streptococcal pharyngitis. Arch Int Med 2012; 172:847-52. ABSTRACT  |  PDF
Zhang Y, Lin FY, Li K, Zhu W, Liu YL, Cao R, Pang R, Lee E, Axelson J, Hensler ME, Wang K, Molohon K, Michell D, Nizet V, Oldfield E. HIV-1 integrase inhibitor inspired anti-bacterials targeting isoprenoid biosynthesis. ChemBioChem 2012; 3:402-6. ABSTRACT  |  PDF  |  Supplemental
Okumura CYM, Hollands A, Tran DN, Olson J, Dahesh S, von Köckritz-Blickwede M, Thienphrapa W, Corle C, Jeung SN, Kotsakis A, Shalwitz RA, Johnson RS, Nizet V. A new pharmacological agent (AKB-4924) stabilizes hypoxia inducible factor (HIF) and increases skin innate defenses against bacterial infection. J Mol Med 2012; 90:1079-89. ABSTRACT  |  PDF
Gonzalez DJ, Okumura CY, Hollands A, Kersten R, Akong-Moore K, Pence MA, Malone CL, Derieux J, Moore BS, Horswill, AR, Dixon JE, Dorrestein PC, Nizet V. Novel phenol soluble modulin derivatives in community- associated methicillin-resistant Staphylococcus aureus identified through imaging mass spectrometry. J Biol Chem 2012l 287:13889-98. ABSTRACT  |  PDF  |  Supplemental
Jongerius I, von Köckritz-Blickwede M, Horsburgh MJ, Ruyken M, Nizet V, Rooijakkers SH. Staphylococcus aureus virulence is enhanced by secreted factors that block innate immune defenses. J Innate Immun 2012; 4:301-11. ABSTRACT  |  Supplemental   |  PDF
Chiang CY, Engel A, Opaluch AM, Ramos I, Maestre AM, Secundino I, De Jesus PD, Nguyen QT, Welch G, Bonamy GM, Miraglia LJ, Orth AP, Nizet V, Fernandez-Sesma A, Zhou Y, Barton GM, Chanda SK. Co-factors required for TLR7 and TLR9- dependent innate immune responses. Cell Host Microbe 2012; 11:306-18. ABSTRACT  |  PDF  |  Supplemental
AAC.jpg McGillivray SM, Tran DN, Ramadoss NS, Alumasa JN, Sakoulas G, Vaughn MM, Zhang DX, Keiler KC, Nizet V. Pharmacological inhibition of the ClpXP protease increases bacterial susceptibility to host cathelicidin antimicrobial peptides and cell-envelope active antibiotics. Antimicrob Agents Chemother 2012; 56:1854-61. ABSTRACT  |  PDF
Lin FY, Zhang Y, Hensler ME, Liu YL, Chow OA, Zhu W, Wang K, Pan R, Thienphrapa W, Nizet V, Oldfield E. Dual dehydrosqualene synthase/squalene synthase inhibitors: Leads for innate immune system-based therapeutics. ChemMedChem 2012; 7:561-4. ABSTRACT  |  PDF
Chang YC, Uchiyama S, Varki A, Nizet V. Leukocyte inflammatory responses provoked by pneumococcal sialidase. mBio 2012; 3:e00220-11. ABSTRACT  |  PDF
Sakoulas G, Nam S-J, Loesgen S, Fenical W, Jensen PR, Nizet V, Hensler M. Novel bacterial metabolite merochlorin A demonstrates activity against multi-drug resistant methicillin-resistant Staphylococcus aureus. PLoS One 2012; 7:e29439. ABSTRACT  |  PDF
AAC.jpg Sakoulas G, Bayer AS, Pogliano J, Tsuji BT, Yang SJ, Mishra NN, Nizet V, Yeaman MR, Moise PA. Ampicillin enhances daptomycin- and cationic host defense peptide-mediated killing of ampicillin- and vancomycin-resistant Enterococcus faecium. Antimicrob Agents Chemother 2012; 56:838-44. ABSTRACT  |  PDF
Guichard A, Nizet V, Bier E. New insights into the biological effects of anthrax toxins: linking cellular to organismal responses. Microb Infect 2012; 14:97-118. ABSTRACT  |  PDF
Kho MF, Bellier A, Balasubramini V, Hu Y, Hsu W, Nielsen-LeRoux C, McGillivray SM, Nizet V, Aroian RV. The pore-forming protein Cry5B elicits the pathogenicity of Bacillus sp. against Caenorhabditis elegans. PLoS One 2011; 2011; 6: e29122. ABSTRACT  |  PDF
Sun P, Maloney KN, Nam SJ, Haste NM, Rajux R, Aalsbersberg W, Jensen PR, Nizet V, Hensler ME, Fenical W. Fijimycins A-C, three new etamycin-class depsipeptides from a marine-derived Streptomyces sp. Bioorg Med Chem 2011; 9:6557-62. ABSTRACT  |  PDF
Nordström T, Movert E, Olin A, Ali SR, Nizet V, Vark A, Areschoug T. Human Siglec-5 inhibitory receptor and immunoglobulin A (IgA) have separate binding sites in the group B streptococcal β protein. J Biol Chem 2011; 286:33981-91. ABSTRACT  |  PDF  |  Supplemental
Cole JN, Barnett TC, Nizet V, Walker MJ. Molecular insight into group A streptococcal invasive disease. Nat Rev Microbiol 2011; 9:724-36. ABSTRACT  |  PDF
Gonzalez D, Haste NM, Hollands A, Fleming TC, Hamby M, Pogliano K, Nizet V, Dorrestein PC. Microbial competition between Bacillus subtilis and Staphylococcus aureus monitored by imaging mass spectrometry. Microbiology 2011; 57:2485–92. ABSTRACT  |  PDF  |  Supplemental
Kinjo Y, Illarionov P, Pei B, Vela JL, Girardi E, Li X, Li Y, Imamura M, Rogers P, Uchiyama S, Khurana A, Ainge GD, Gibson D, Kawahara K, Yesilkaya H, Andrew P, Wong CH, Painter G, Kawakami K, Nizet V, Besra GS, Tsuji M, Zajonc DM, Kronenberg M. Invariant NKT cells recognize glycolipids from pathogenic Gram-positive bacteria. Nat Immunol 2011; 12:966-74. ABSTRACT  |  PDF  |  Supplemental
Fine AM, Nizet V, Mandl KD. Improved diagnostic accuracy of group A streptococcal pharyngitis using real-time biosurveillance. Ann Intern Med 2011; 155:345-52. ABSTRACT  |  PDF
Carland TM, Locke JB, Nizet V, Gerwick L. Differential expression and intrachromosomal evolution of the sghC1q genes in zebrafish (Danio rerio). Dev Comp Immunol 2012; 36:31-8. ABSTRACT  |  PDF
Zinkernagel AS, Hruz P, Uchiyama S, von Köckritz-Blickwede M, Schuepbach RA, Hayashi T, Carson DA, Nizet V. Importance of Toll like receptor 9 in host defense against M1T1 group A Streptococcus infections. J Innate Immun 2011; 4:213-8. ABSTRACT  |  PDF  |  Supplemental
Sjögren J, Collin M, Nizet V, Hollands A. Study of the IgG endoglycosidase EndoS in group A streptococcal phagocyte resistance and virulence. BMC Microbiol 2011; 11:120. ABSTRACT  |  PDF
CID.jpg Dhand A, Bayer AS, Pogliano J, Bolaris M, Nizet V, Wang G, Sakoulas G. Anti-staphylococcal beta-lactams increase daptomycin binding and activity in eradicating persistent bacteremia due to methicillin-resistant Staphylococcus aureus. Clin Infect Dis 2011; 53: 158-63. ABSTRACT  |  PDF
Ali SR, Timmer AM, Bilgrami S, Park EJ, Eckmann L, Nizet V, Karin M. Inhibition of p38 signaling by Bacillus anthracis lethal toxin induces ATP release and inflammasome activation via ATP leakage. Immunity 2011; 35:34-44. ABSTRACT  |  PDF  |  Supplemental
PlosPath.png Chang YC, Wang Z, Flax LA, Xu D, Esko JD Nizet V, Baron MJ. Glycosaminoglycan binding facilitates entry of a bacterial pathogen into central nervous systems. PLoS Pathogens 2011; 7:e1002082 ABSTRACT  |  PDF  |  Supplemental
AAC.jpg Haste NM, Hughes CC, Tran DN, Fenical W, Jensen PR, Nizet V, Hensler ME. Pharmacological properties of the marine natural product marinopyrrole A against methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother 2011; 55:3305-12. ABSTRACT  |  PDF
Amelung S, Nerlick A, Rohde M, Spellerberg B, Cole JN, Nizet V, Chhatwal GS, Talay SR. The FbaB-type fibronectin-binding protein of Streptococcus pyogenes promotes specific invasion into endothelial cells. Cell Microbiol 2011; 13:1200-11. ABSTRACT  |  PDF
Kisseleva T, von Köckritz-Blickwede M, Reichart D, McGillvray SM, Wingender G, Kronenberg M, Glass CK, Nizet V, Brenner DA. Fibrocyte-like cells recruited to the spleen support innate and adaptive immune responses to acute injury or infection. J Mol Med 2011; 89:997-1013. ABSTRACT  |  PDF  |  Supplemental
Marine-drugs.png Haste NM, Farnaes L, Perera VR, Jensen PR, Fenical W, Nizet V, and Hensler ME. Bactericidal kinetics of marine derived napyradiomycins against contemporary methicillin-resistant Staphylococcus aureus. Marine Drugs 2011; 9:680-9. ABSTRACT  |  PDF
Macheboeuf P, Buffalo C, Fu CY, Zinkernagel AS, Cole JN, Johnson JE, Nizet V, Ghosh P. Streptococcal M1 protein constructs a pathological host fibrinogen network. Nature 2011; 472:64-8. ABSTRACT  |  PDF  |  Supplemental
Yang H, Sikavi C, Tran K, McGillivray SM, Nizet V, Yung M, Chang A, Miller JH. Papillation in Bacillus anthracis colonies: a tool for finding new mutators. Mol Microbiol 2011; 79: 1276-93. ABSTRACT  |  PDF
Hsu LC, Enzler T, Seita J, Timmer AM, Lee CY, Lai TY, Yu GY, Lai LC, Temkin V, Nizet V, Weissman IL, Karin M. IL-1β-driven neutrophilia preserves antibacterial defense in the absence of the kinase IKKβ. Nat Immunol 2011; 12:144-50. ABSTRACT  |  PDF  |  Supplemental
Nicolaou KC, Simmons NL, Chen JS, Haste NM, Nizet V. Total synthesis and biological evaluation of marinopyrrole A and analogs. Tetrahed Lett 2011; 52:2041-3. ABSTRACT  |  PDF
Reiss A, Braun JS, Jäger K, Freyer D, Laube G, Nizet V, Bührer C, Felderhoff-Mueser U, Weber J. Bacterial pore forming cytolysins induce neuronal damage in a rat model of neonatal meningitis. J Infect Dis 2010; 203:393-400. ABSTRACT  |  PDF
Chow OA, von Köckritz-Blickwede M, Bright AT, Hensler ME, Zinkernagel AS, Cogen AL, Gallo RL, Monestier M, Wang Y, Glass CK, Nizet V. Statins enhance formation of phagocyte extracellular traps. Cell Host Microbe 2010; 8:445-54. ABSTRACT  |  PDF  |  Supplemental
Guichard A, McGillivray SM, Moreno BC, van Sorge NM, Nizet V, Bier E. Anthrax toxins cooperatively inhibit endocytic recycling by the Rab11/Sec15 exocyst. Nature 2010; 467:854-8. ABSTRACT  |  PDF  |  Supplemental
Berends ET, Horswill AR, Haste NM, Nizet V, von Köckritz-Blickwede M. Nuclease expression by Staphylococcus aureus facilitates escape from neutrophil extracellular traps. J Innate Immun 2010; 2:576-86. (cover article) ABSTRACT  |  PDF  |  Supplemental
Cole JN, Pence MA, von Köckritz-Blickwede M, Hollands A, Gallo RL, Walker MJ, Nizet V. M protein and hyaluronic acid capsule are essential for in vivo selection of covRS mutations characteristic of invasive M1T1 group A Streptococcus. MBio 2010; 1:e00191-10. ABSTRACT  |  PDF
Pence MA, Rooijakkers SH, Cogen AL, Cole JN, Hollands A, Gallo RL, Nizet V. Streptococcal inhibitor of complement (SIC) promotes innate immune resistance phenotypes of invasive M1T1 group A Streptococcus. J Innate Immun 2010; 2:587-95. ABSTRACT  |  PDF  |  Supplemental
Nizet V. Accentuate the (Gram) positive. J Mol Med 2010; 88:93-5. ABSTRACT  |  PDF
Nizet V. Bacteria and phagocytes: Mortal enemies. J Innate Immun 2010; 2:505-7. ABSTRACT  |  PDF
Maamary PG, Sanderson-Smith ML, Aziz RK, Hollands A, Cole JN, McKay FC, McArthur JD, Kirk JK, Cork AJ, Keefe RJ, Kansal RG, Sun H, Taylor WL, Chhatwal GS, Ginsburg D, Nizet V, Kotb M, Walker MJ. Parameters governing invasive disease propensity of non-M1 serotype group A streptococci. J Innate Immun 2010; 596-606. ABSTRACT  |  PDF  |  Supplemental
Liu WT, Yang YL, Xu Y, Lamsa A, Haste NM, Yang JY, Ng J, Gonzalez DJ, Ellermeier CD, Straight PD, Pevzner P, Pogliano J, Nizet V, Pogliano K, Dorrestein PC. Imaging mass spectrometry of intraspecies metabolic exchange revealed the cannibalistic factors of Bacillus subtilis. Proc Natl Acad Sci USA 2010; 107:16286-90. ABSTRACT  |  PDF  |  Supplemental
Derbal S, Hensler M, Fang W, Nizet V, Ghedira K, Nefzi A. On resin amino acid side chain attachment strategy for the head to tail synthesis of new glutamine containing gramicidin-S analogs and their antimicrobial activity. Bioorg Med Chem Lett 2010; 20:5701–4. ABSTRACT  |  PDF
Zhao HW, Zhou D, Nizet V, Haddad GG. Experimental selection for Drosophila survival in extremely high O2 environments. PLoS One 2010; 5:11701. ABSTRACT  |  PDF
JEM.png Taylor RE, Gregg C, Padler-Karavani V, Ghaderi D, Yu H, Sorensen RU, Chen X, Inostroza J, Nizet V, Varki A. Novel mechanism for the generation of human xeno-autoantibodies against the nonhuman sialic acid N-glycolylneuraminic acid. J Exp Med 2010; 207:1637-46. ABSTRACT  |  PDF
Rooijakkers SH, Rasmussen SL, McGillivray SM, Mason AB, Friedlander AM, Nizet V. Human transferrin confers serum resistance against Bacillus anthracis. J Biol Chem 2010; 85:27609-13. ABSTRACT  |  PDF
Gonzalez DJ, Lee SW, Hensler ME, Dahesh S, Markley AL, Mitchell DA, Banderia N, Nizet V, Dixon JE, Dorrestein PC. Clostridiolysin S: a post-translationally modified biotoxin from Clostridium botulinum. J Biol Chem 2010; 285:28220-8. ABSTRACT  |  PDF  |  Supplemental
Aziz RK, Nizet V. Perspective: Pathogen microevolution in high resolution. Sci Transl Med 2010; 2:16ps4. ABSTRACT  |  PDF
Kaur SJ, Nerlich A, Rohde M, Fulde MA, Zähner D, Hanski E, Zinkernagel A, Nizet V, Chhatwal GS, Talay SR. The CXC chemokine-degrading protease SpyCep of Streptococcus pyogenes promotes its uptake into endothelial cells. J Biol Chem 2010; 285:27798-805. ABSTRACT    |  Supplemental   |  PDF
Haste NM, Perera V, Maloney KN, Tran DN, Jensen PR, Fenical W, Nizet V and Hensler ME. Activity of the streptogramin antibiotic etamycin against methicillin-resistant Staphylococcus aureus. J Antibiot 2010; 63:219-24. ABSTRACT    |  Supplemental   |  PDF
Hollands A, Pence MA, Timmer AM, Osvath SR, Turnbull L, Whitchurch CB, Walker MJ, Nizet V. A genetic switch to hypervirulence impairs colonization phenotypes of the globally disseminated group A Streptococcus M1T1 clone. J Infect Dis 2010; 202:11-9. ABSTRACT  |  PDF
Weiman S, Uchiyama S, Lin FC, Varki A, Nizet V, Lewis AL. O-Acetylation of sialic acid on group B Streptococcus inhibits neutrophil suppression and virulence. Biochem J 2010; 428:163-8. ABSTRACT  |  PDF
Stockmann C, Kerdiles Y, Nomaksteinsky M, Weidemman A, Takeda N, Doedens A, Torres-Collado AX, Iruela-Arispe L, Nizet V, Johnson RS. Loss of inflammatory cell-derived vascular endothelial growth factor accelerates fibrosis. Proc Natl Acad Sci USA 2010; 107:4329-34. ABSTRACT  |  PDF
Kurupati P, Turner CE, Tziona I, Nohadani M, Stamp GW, Zinkernagel AS, Nizet V, Edwards RJ, Sriskandan S. Chemokine-cleaving Streptococcus pyogenes protease SpyCEP is necessary and sufficient for bacterial dissemination within soft tissues and the respiratory tract. Mol Microbiol 2010; 76:1387-97. ABSTRACT  |  PDF
Locke JB, Ostland VE, Vicknair MR, Nizet V, Buchanan JT. Evaluation of Streptococcus iniae killed bacteria and live attenuated vaccines in hybrid striped bass through injection and bath immersion. Dis Aquat Organism 2010; 89:117-23. ABSTRACT  |  PDF
Crotty Alexander LE, Maisey HC, Timmer AM, Rooijakkers SHM, Gallo RL, von Köckritz-Blickwede M, Nizet V. M1T1 group A streptococcal pili promote epithelial colonization but diminish systemic virulence through neutrophil extracellular entrapment. J Mol Med 2010; 88:371-81. ABSTRACT  |  PDF
Cogen AL, Yamasaki K, Muto J, Sanchez KM, Crotty-Alexander L, Tanios J, Lai Y, Kim JE, Nizet V, Gallo RL. Staphylococcus epidermidis antimicrobial δ-toxin (phenol soluble modulin-γ) cooperates with host antimicrobial peptides to kill group A Streptococcus. PLoS One 2010; 5:e8557. ABSTRACT  |  PDF
Milani CJ, Aziz RK, Locke JB, Dahesh S, Nizet V, Buchanan JT. The novel polysaccharide deacetylase homologue Pdi contributes to virulence of the aquatic pathogen Streptococcus iniae. Microbiology 2010; 156:543-54. ABSTRACT  |  PDF
Cogen AL, Yamasaki K, Sanchez KM, Dorschner RA, Lai Y, McLeod D, Torpey J, Otto M, Nizet V, Kim JE, Gallo RL. Selective antimicrobial action is provided by phenol soluble modulins derived from Staphylococcus epidermidis, a normal resident of the skin. J Invest Derm 2010; 130:192-200. ABSTRACT  |  PDF
Blood.png von Köckritz-Blickwede M, Chow OA, Nizet V. Fetal calf serum contains heat-stable nucleases that degrade neutrophil extracellular traps. Blood 2009; 114:5245-6. ABSTRACT  |  PDF
Glycobiology.png Weiman S, Dahesh S, Carlin AF, Varki A, Nizet V, Lewis AL. Genetic and biochemical modulation of sialic acid O-acetylation on group B Streptococcus: phenotypic and functional impact. Glycobiology 2009; 19:1204-13. ABSTRACT  |  PDF
J-leuk-bio.png Jann N, Schmaler M, Kristian S, Gallo R, Nizet V, Peschel A, Landmann R. Neutrophil antimicrobial defense against Staphylococcus aureus is mediated by phagolysosomal but not extracellular trap-associated cathelicidin. J Leukocyte Biol 2009; 86:1159-69. ABSTRACT  |  PDF
Liu GY, Nizet V. Color me bad: microbial pigments as virulence factors. Trends Microbiol 2009; 17:406-13. ABSTRACT  |  PDF
JEM.png Uchiyama S, Carlin AF, Weiman S, Khosravi A, Banerjee A, Quach D, Hightower G, Mitchell TJ, Doran KS, Nizet V. The surface-anchored NanA protein promotes pneumococcal brain endothelial cell invasion. J Exp Med 2009; 206:1845-52. ABSTRACT    |  Supplemental   |  PDF
Nizet V, Johnson RS. Interdependence of hypoxic and innate immune responses. Nat Rev Immunol 2009; 9:609-17. (cover article) ABSTRACT  |  PDF
Lewis A, Desa N, Hansen E, Knirel Y, Gordon J, Gagneux P, Nizet V, Varki A. Innovations in host and microbial sialic acid biosynthesis revealed by phylogenomic prediction of nonulosonic acid structure. Proc Natl Acad Sci USA 2009; 106:13552-7. ABSTRACT  |  PDF  |  Supplemental
Tseng CW, Kyme P, Low J, Rocha MA, Alsabeh R, Miller LG, Otto M, Arditi M, Diep BA, Nizet V, Doherty TM, Beenhouwer DO, Liu GY. Staphylococcus aureus Panton-Valentine leukocidin contributes to inflammation and muscle tissue injury. PLoS One 2009; 4:e6837. ABSTRACT  |  PDF  |  Supplemental
Actor J, Nizet V, Marshall J, Hershon V. Milk protein fends off sepsis in premature babies. Nat Med 2009; 15:1362  ABSTRACT  |  PDF
JEM.png Carlin AF, Chang YC, Areschoug T, Lindahl G, Hurtado-Ziola N, King CC, Varki A, Nizet V. Group B Streptococcus suppression of phagocyte functions by protein-mediated engagement of human Siglec 5. J Exp Med 2009; 206: 1691-9. (cover article) ABSTRACT  |  PDF
Hruz P, Zinkernagel AS, Jenikova G, Botwin G, Hugot JP, Karin M, Nizet V, Eckmann L. NOD2 contributes to cutaneous defense against Staphylococcus aureus through α-toxin-dependent innate immune activation. Proc Natl Acad Sci USA 2009; 106:12873-8. ABSTRACT  |  PDF  |  Supplemental
McGillivray SM, Ebrahimi CM, Fisher N, Sabet M, Chen Y, Haste NM, Aroian RV, Gallo RL, Guiney DG, Friedlander AM, Koehler TM, Nizet V. ClpX contributes to innate defense peptide resistance and virulence phenotypes of Bacillus anthracis. J Innate Immun 2009; 1:494-506. ABSTRACT  |  PDF
von Köckritz-Blickwede M, Nizet V. Innate immunity turned inside-out: Antimicrobial defense by phagocyte extracellular traps. J Mol Med 2009; 87:775–83. ABSTRACT  |  PDF
Pinheiro da Silva F, Gallo RL, Nizet V. Differing effects of exogenous or endogenous cathelicidin on macrophage Toll-like receptor signaling. Immunol Cell Biol 2009; 87:496-500. ABSTRACT  |  PDF
Song Y, Liu CI, Lin FY, No JH, Hensler ME, Liu YL, Jeng WY, Low J, Liu GY, Nizet V, Wang AHJ, Oldfield EO. Inhibition of staphyloxanthin virulence factor biosynthesis in Staphylococcus aureus: in vitro, in vivo, and crystallographic results. J Med Chem 2009; 52:3869-80. ABSTRACT  |  PDF
Mitchell DA, Lee SW, Pence MA, Markley AL, Limm JD, Nizet V, Dixon JE. Structural and functional dissection of the heterocyclic peptide cytotoxin streptolysin S. J Biol Chem 2009; 284:13004-12. ABSTRACT  |  PDF
Cox KH, Ruiz-Bustos E, Courtney HS, Dale JB, Pence MA, Nizet V, Aziz RK, Gerling I, Price SM, Hasty DL. Inactivation of DltA modulates virulence factor expression in Streptococcus pyogenes. PLoS One 2009; e:5366. ABSTRACT  |  PDF
Navarini-Meury AA, Lang KS, Verschoor A, Recher M, Zinkernagel AS, Nizet V, Odermatt B, Hengartner H, Zinkernagel RM. Innate immune-induced depletion of bone marrow neutrophils aggravates systemic bacterial infection. Proc Natl Acad Sci USA 2009; 106:7107-12. ABSTRACT  |  PDF  |  Supplemental  |  Commentary
van Sorge NM, Quach D, Sullam PM, Nizet V, Doran KS. The group B streptococcal Srr-1 glycoprotein mediates penetration of the blood-brain barrier. J Infect Dis 2009; 199:1479-87. Cover Article ABSTRACT  |  PDF
Blood.png Carlin AF, Uchiyama S, Chang YC, Lewis AL, Nizet V, Varki A. Molecular mimicry of host sialylated glycans allows a bacterial pathogen to engage neutrophil Siglec-9 and dampen the innate immune response. Blood 2009; 113:3333- 6. ABSTRACT  |  PDF
Lauth X, von Kockritz-Blickwede M, McNamara CW, Myskowski S, Zinkernagel AS, Beall B, Ghosh P, Gallo RL, Nizet V. M1 protein allows group A streptococcal survival in phagocyte extracellular traps through cathelicidin inhibition. J Innate Immun 2009; 1:202-14. ABSTRACT  |  PDF
Song Y, Lin FY, Yin F, Hensler ME, Rodrigues-Poveda CA, Mukkamala D, Cao R, Morita CT, González- Pacanowska D, Nizet V, Oldfield EO. Phosphonosulfonates are potent, selective inhibitors of dehydrosqualene synthase and staphyloxanthin biosynthesis in Staphylococcus aureus. J Med Chem 2009; 52:976-88. ABSTRACT  |  PDF
Pinheiro da Silva F, Nizet V. Cell death during sepsis: Integration of disintegration in the inflammatory response to overwhelming infection. Apoptosis 2009; 14:509-21. ABSTRACT  |  PDF
Emerg-Infec-Dis.png Sendi P, Johansson L, Dahesh S, van Sorge NM, Darenberg J, Norgren M, Sjölin J, Nizet V, Norrby-Teglund A. Bacterial phenotype variants in group B streptococcal toxic shock syndrome. Emerg Infect Dis 2009; 15:223-32. ABSTRACT  |  PDF
Courtney HS, Ofek I, Penfound T, Nizet V, Pence MA, Kreikemeyer B, Podbielbski A, Hasty DL, Dale JB. Relationship between expression of the family of M proteins and lipoteichoic acid to hydrophobicity and biofilm formation in Streptococcus pyogenes. PLoS One 2009; e4166. ABSTRACT  |  PDF
Timmer AM, Timmer JC, Pence MA, Hsu LC, Ghochani M, Frey TG, Karin M, Salvesen GS, Nizet V. Streptolysin O promotes group A Streptococcus immune evasion by accelerated macrophage apoptosis. J Biol Chem 2009; 284:862-71. ABSTRACT  |  PDF
Hollands A, Aziz RK, Kansal R, Kotb M, Nizet V, Walker MJ. A naturally occurring mutation in ropB suppresses SpeB expression and reduces M1T1 group A streptococcal systemic virulence. PLoS One 2008 3:e4102. ABSTRACT  |  PDF
Gallo RL, Nizet V. Innate barriers against infection and associated disorders. Drug Disc Today Dis Mech 2008; 5:145-52. ABSTRACT  |  PDF
Maisey HC, Doran KS, Nizet V. Recent advances in understanding the molecular basis of group B Streptococcus virulence. Exp Rev Mol Med 2008; 10:e27. ABSTRACT  |  PDF
Buchanan JT, Colvin KM, Vicknair MR, Patel SK, Timmer AM, Nizet V. Strain-associated virulence patterns of Streptococcus iniae in hybrid-striped bass. Vet Microbiol 2008; 131:145-53. ABSTRACT  |  PDF  
Zinkernagel AC, Timmer AM, Pence MA, Locke JB, Buchanan JT, Turner CE, Mishalian I, Sriskandan S, Hanski E, Nizet V. IL-8 protease SpyCEP/ScpC promotes group A streptococcal resistance to neutrophil killing. Cell Host Microbe 2008; 4:170-8. ABSTRACT  |  PDF  |  Supplemental
JEM.png Timmer AM, Nizet V. Commentary: IKKβ/NF-κB and the miscreant macrophage. J Exp Med 2008; 205:1255-9. ABSTRACT  |  PDF
AAC.jpg Dahesh S, Hensler ME, van Sorge NM, Gertz, RE, Schrag S, Nizet V, Beall BW. Point mutation in the group B streptococcal pbp2x gene conferring decreased susceptibility to β-lactam antibiotics. Antimicrob Agents Chemother 2008; 52:2915-8. ABSTRACT  |  PDF
Locke JB, Aziz RK, Vicknair MR, Nizet V, Buchanan JT. Streptococcus iniae M-like protein contributes to virulence in fish and is a target for live-attenuated vaccine development. PLoS One 2008; 3:e2824. ABSTRACT  |  PDF
Peyssonnaux C, Boutin A, Zinkernagel A, Datta V, Nizet V, Johnson RS. Critical role of HIF-1α in keratinocyte defense against bacterial infection. J Invest Dermatol 2008; 128:1964-8. ABSTRACT  |  PDF
Hensler ME, Miyamoto S, Nizet V. Group B streptococcal β-hemolysin/cytolysin directly impairs cardiomyocyte viability and function. PLoS One 2008; 3:e2446. ABSTRACT  |  PDF
Hsu LC, Ali R, McGillivray S, Tseng PH, Mariathasan S, Humke E, Eckmann L, Powell J, Nizet V, Dixit V, Karin M. A NOD2-NALP1 complex mediates caspase-1 dependent IL-1β secretion in response to Bacillus anthracis infection and muramyl dipeptide. Proc Natl Acad Sci USA 2008; 105:7803-08. ABSTRACT  |  PDF  |  Supplemental
Kraus D, Herbert S, Kristian S, Nizet V, Götz F, Peschel A. The GraRS regulatory system controls in vivo susceptibility of Staphylococcus aureus to antimicrobial host defenses. BMC Microbiol 2008; 8:85. ABSTRACT  |  PDF
Grewal PK, Uchiyama S, Ditto D, Varki N, Le DT, Nizet V, Marth JD. The Ashwell receptor mitigates the lethal coagulopathy of sepsis. Nat Med 2008; 14:648-55. ABSTRACT  |  PDF  |  Commentary
Maisey HC, Hensler ME, Quach D, Liu GY, Gallo RL, Nizet V, Doran KS. A group B streptococcal pilus protein promotes phagocyte resistance and systemic virulence. FASEB J 2008; 22:1715-24. ABSTRACT    |  ICS   |  PDF
Rius J, Guma M, Schachtrup C, Akassoglou K, Zinkernagel AS, Nizet V, Johnson RS, Haddad GG, Karin M. NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α. Nature 2008; 453:807-11. ABSTRACT  |  PDF  |  Supplemental
Meluzzi D, Zheng W, Hensler M, Nizet V, Dorrestein PC. Top-down mass spectrometry on low-resolution instruments: characterization of phosphopantheteinylated carrier domains in polyketide and non-ribosomal biosynthetic pathways. Bioorg Med Chem Lett 2008; 18:3107-11. ABSTRACT  |  PDF
Lee SW, Mitchell DA, Markley AL, Hensler ME, Gonzalez D, Wohlrab A, Dorrestein PC, Nizet V, Dixon JE. Discovery of a widely distributed toxin biosynthetic gene cluster. Proc Natl Acad Sci USA 2008; 105:5879-84. ABSTRACT  |  PDF  |  Supplemental  |  Commentary
Park B, Nizet V, Liu GY. Role of Staphylococcus aureus catalase in niche competition against Streptococcus pneumoniae. J Bacteriol 2008; 190:2275-8. ABSTRACT  |  PDF
McNamara CW, Zinkernagel AS, Macheboeuf P, Cunningham MW, Nizet V, Ghosh P. Coiled-coil irregularities and instabilities in Group A Streptococcus M1 are required for virulence functions. Science 2008; 319:1405-8. ABSTRACT  |  PDF
Liu C-I, Liu GY, Song Y, Yin F, Hensler ME, Jeng WY, Nizet V*, Wang AH*, Oldfield E*. A cholesterol biosynthesis inhibitor blocks Staphylococcus aureus virulence. Science 2008; 319:391-4. *share senior authorship ABSTRACT  |  PDF  |  Supplemental  |  Commentary  |  Commentary  |  Commentary   |  Commentary
Nizet V, Rothenberg ME. News & Views: Mitochondrial missile defense. Nat Med 2008; 9:910-2. ABSTRACT  |  PDF
Gillen CM, Courtney HS, Schulze K, Rohde M, Wilson MR, Timmer AM, Guzman CA, Nizet V, Chhatwal GS, and Walker MJ. Apolipoprotein AI binding and epithelial cell binding by the serum opacity factor protein of Streptococcus pyogenes are functionally discrete. J Biol Chem 2008; 283:6359-66. ABSTRACT  |  PDF
Cogen AL, Nizet V, Gallo RL. Skin microbiota: A source of disease or defence? Br J Dermatol 2008; 158:442-55. ABSTRACT  |  PDF
Zinkernagel AC, Peyssonnaux C, Johnson RS, Nizet V. Pharmacological augmentation of HIF-1α with mimosine boosts the bactericidal capacity of phagocytes. J Infect Dis 2008; 197:214-7. ABSTRACT  |  PDF
Peyssonnaux C, Nizet V, Johnson R. Role of the hypoxia-inducible factors iron metabolism. Cell Cycle 2008; 7:28-32. ABSTRACT  |  PDF
Hensler ME, Quach D, Hsieh C.J., Doran KS, Nizet V. CAMP factor is not essential for systemic virulence of group B Streptococcus. Microb Pathog 2008; 44:84-8. ABSTRACT  |  PDF
Cole JN, Aquilina JA, Hains PG, Henningham A, Sriprakash KS, Caparon MG, Nizet V, Kotb M, Cordwell SJ, Djordjevik SP, Walker MJ. Role of group A Streptococcus HtrA in the maturation of SpeB protease. Proteomics 2007; 7:4488-98. ABSTRACT  |  PDF
Zinkernagel AS, Johnson RS, Nizet V. Hypoxia inducible factor (HIF) function in innate immunity and infection. J Mol Med 2007; 85:1339-46. ABSTRACT  |  PDF
Lewis AL, Cao H, Patel SK, Diaz S, Ryan W, Carlin AF, Lewis WG, Varki A, Chen X, Nizet V. NeuA O-acetylesterase activity modulates O-acetylation of capsular sialic acids in group B Streptococcus. J Biol Chem 2007; 282:27562-71. ABSTRACT  |  PDF
Walker MJ, Hollands A, Sanderson-Smith M, Cole JN, Kirk JK, Henningham A, McArthur JD, Dinkla K, Aziz RK, Kansal RG, Simpson AJ, Buchanan JT, Chhatwal GS, Kotb M, Nizet V. DNase Sda1 provides selection pressure for a switch to invasive group A streptococcal infection. Nat Med 2007; 13:981-5. ABSTRACT  |  PDF  |  Supplemental   |  Commentary
Blood.png Bayele HK, Peyssonnaux C, Giatromanolaki A, Arrais-Silva WW, Mohamed HS, Collins H, Giorgio S, Koukourakis M, Johnson RS, Blackwell JM, Nizet V, Sria SK. HIF-1α regulates heritable variation and allele expression phenotypes of the macrophage immune response gene SLC11A1 from a Z-DNA-forming microsatellite. Blood 2007; 110:3039-48. ABSTRACT  |  PDF
Nizet V. Understanding how leading bacterial pathogens subvert innate immunity to reveal novel therapeutic targets. J Allergy Clin Immunol 2007; 120:13-22. ABSTRACT  |  PDF
Peyssonnaux C, Zinkernagel AS, Scheupbach RA, Rankin E, Vaulont S, Haase VH, Nizet V*, Johnson RS*. Regulation of iron homeostasis by the hypoxia inducible transcription factors (HIFs). J Clin Invest 2007; 117:1926-32. *share senior authorship ABSTRACT  |  PDF
Peyssonnaux C, Cejudo-Martin P, Doedens A, Zinkernagel A, Johnson RS, Nizet V. Cutting edge: Essential role of hypoxia inducible factor-1α in development of LPS-induced sepsis. J Immunol 2007; 178:7516-9. ABSTRACT  |  PDF
Locke JB, Colvin KM, Varki N, Vicknair MR, Nizet V, Buchanan JT. The Streptococcus iniae β-hemolysin streptolysin S is a virulence factor in fish infection. Dis Aquat Organ 2007; 76:17-26. ABSTRACT  |  PDF
Zinkernagel AS, Nizet V. Staphylococcus aureus: a blemish on skin immunity. Cell Host Microbe 2007; 1:115-116. ABSTRACT  |  PDF
Kristian SA, Timmer AM, Liu GY, Lauth X, Sal-Man N, Rosenfeld Y, Shai Y, Gallo RL, Nizet V. Impairment of innate immune killing mechanisms by bacteriostatic antibiotics. FASEB J 2007; 21:1107-26. ABSTRACT  |  PDF
FutureMicro.jfif Kwinn LA, Nizet V. How group A Streptococcus circumvents host phagocyte defenses. Future Microbiol 2007; 2:75-84. ABSTRACT  |  PDF
Locke JB, Colvin KM, Datta AK, Patel SK, Naidu NN, Neely MN, Nizet V, Buchanan JT. Streptococcus iniae capsule impairs phagocytic clearance and contributes to virulence in fish. J Bacteriol 2007; 189:1279-87. ABSTRACT  |  PDF
Kwinn LA, Khosravi A, Aziz RK, Timmer AM, Doran KS, Kotb M, Nizet V. Genetic characterization and virulence role of the RALP3/LSAP locus upstream of the streptolysin S operon in invasive M1T1 group A Streptococcus. J Bacteriol 2007; 189:1322-9. ABSTRACT  |  PDF
Carlin AF, Lewis AL, Varki A, Nizet V. Group B streptococcal capsular sialic acid interacts with Siglecs (immunoglobulin-like lectins) on human leukocytes. J Bacteriol 2007; 189:1231-7. ABSTRACT  |  PDF
Maisey HC, Hensler M, Nizet V, Doran KS. Group B streptococcal pili proteins contribute to adherence and invasion of brain microvascular endothelial cells. J Bacteriol 2007; 189:1464-7. ABSTRACT  |  PDF
Chen Y, Corriden R, Inoie Y, Yip L, Hashiguchi N, Zinkernagel A, Nizet V, Insel PA, Junger WG. ATP release guides neutrophil chemotaxis via P2Y2 and A3 receptors. Science 2006; 314:1792-5. ABSTRACT  |  PDF  |  Supplemental
Dehority W, Uchiyama W, Khosravi A, Nizet V. Brain abscess caused by Streptococcus pyogenes in a previously healthy child. J Clin Microbiol 2006; 44:4613-5. ABSTRACT  |  PDF
Hamilton A, Popham DL, Carl DJ, Lauth X, Nizet V, Jones AL. Penicillin-binding protein 1a promotes resistance of group B Streptococcus to antimicrobial peptides. Infect Immun 2006; 74:6179-87. ABSTRACT  |  PDF
EMBO.png Hidalgo-Grass C, Mishalian I, Dan-Goor M, Belotserkovsky I, Eran Y, Nizet V, Peled A Hanski E. A streptococcal protease that locally degrades CXC chemokines subverting innate immune responses in the skin. EMBO J 2006; 25:4628-37. ABSTRACT  |  PDF
Hensler ME, Bernstein G, Nizet V, Nefzi A. Pyrrolidine bis-cyclic guanidines with antimicrobial activity against drug resistant Gram-positive pathogens identified from a mixture-based combinatorial library. Bioorg Med Chem Lett 2006; 16:5072-9. ABSTRACT  |  PDF
Timmer AM, Kristian SA, Datta V, Jeng A, Gillen CM, Walker MJ, Beall B, Nizet V. Serum opacity factor promotes group A streptococcal epithelial cell invasion and virulence. Mol Microbiol 2006; 62:15-25. ABSTRACT    |  ICS   |  PDF
Cole JN, McArthur JD, McKay FC, Sanderson-Smith ML, Cork AJ, Ranson M, Rohde M, Itzek A, Sun H, Ginsburg D, Kotb M, Nizet V, Chhatwal GS, Walker MJ. Trigger for group A streptococcal M1T1 invasive infection. FASEB J 2006; 20:1745-7. ABSTRACT  |  PDF
Lewis ML, Hensler ME, Varki A, Nizet V. The group B streptococcal sialic acid O-acetyltransferase is encoded by neuD, a conserved component of bacterial sialic acid biosynthetic gene clusters. J Biol Chem 2006; 281:11186-92. ABSTRACT  |  PDF
Blood.png Peyssonnaux C, Zinkernagel AS, Datta V, Lauth X, Johnson RS, Nizet V. TLR4-dependent hepcidin expression by myeloid cells in response to bacterial pathogens. Blood 2006 107:3727-32. ABSTRACT  |  PDF
Buchanan JT, Simpson AJ, Aziz RK, Liu GY, Kristian SA, Kotb M, Feramisco J, Nizet V. DNase expression allows the pathogen group A Streptococcus to escape killing in neutrophil extracellular traps. Curr Biol 2006 16:396-400. ABSTRACT  |  PDF
Karin M, Lawrence T, Nizet V. Innate immunity gone awry: Mechanisms linking microbial infections to chronic inflammatory diseases and cancer. Cell 2006; 124:823-5. ABSTRACT  |  PDF
Curr-Iss-Mol-Biol.png Nizet V. Antimicrobial peptide resistance mechanisms of human bacterial pathogens. Curr Issues Mol Biol 2006; 8:11- 26. ABSTRACT  |  PDF
Dorschner RA, Lopez-Garcia B, Peschel A, Kraus D, Morikawa K, Nizet V, Gallo RL. The mammalian ionic environment induces microbial susceptibility to innate defense peptides. FASEB J 2006; 20:35-42. ABSTRACT  |  PDF
Braff MH, Zaiou M, Fierer J, Nizet V, Gallo R. Keratinocyte production of cathelicidin provides direct antimicrobial activity against bacterial skin pathogens. Infect Immun 2005; 73:6771-81. ABSTRACT  |  PDF
Buchanan JT, Stannard JA, Lauth X, Ostland VE, Powell HC, Westerman ME, Nizet V. Streptococcus iniae phosphoglucomutase is a virulence factor and target for vaccine development. Infect Immun 2005; 73:6935-44. ABSTRACT  |  PDF
Doran KS, Engelson EJ, Khosravi A, Maisey HC, Fedtke I, Equils O, Michelsen KS, Arditi M, Peschel A, Nizet V. Group B Streptococcus blood-brain barrier invasion depends upon proper cell surface anchoring of lipoteichoic acid. J Clin Invest 2005; 115:2499-507. ABSTRACT  |  PDF  |  Commentary
Kristian SA, Datta V, Weidenmaier C, Kansal R, Fedtke I, Peschel A, Gallo RL, Nizet V. D-alanylation of teichoic acids promotes group A Streptococcus antimicrobial peptide resistance, neutrophil survival, and epithelial cell invasion. J Bacteriol 2005; 187:6719-25. ABSTRACT    |  ICS   |  PDF
Georgel P, Crozat K, Lauth X, Makrantonaki E, Seltmann H, Sovath S, Heobe K, Du X, Rutschmann S, Jiang Z, Bigby T, Nizet V, Zouboulis CC, Beutler B. A Toll-like receptor 2-responsive lipid effector pathway protects mammals against skin infections with Gram-positive bacteria. Infect Immun 2005; 73:4512-21. ABSTRACT  |  PDF
JEM.png Liu GY, Essex A, Buchanan JT, Datta V, Hoffman HA, Bastian J, Fierer J, Nizet V. Staphylococcus aureus golden pigment impairs neutrophil killing and promotes virulence through its antioxidant activity. J Exp Med 2005; 202:209-15. (cover article) ABSTRACT    |  Commentary   |  PDF
Peyssonnaux C, Datta V, Doedens A, Theodorakis EA, Gallo RL, Hurtado-Ziola N, Nizet V*, Johnson RS*. HIF-1 expression regulates the bactericidal capacity of phagocytes. J Clin Invest 2005 115:1806-15. *share senior authorship. ABSTRACT  |  PDF  |  Commentary
Braff MH, Bardan A, Nizet V, Gallo RL. Cutaneous defense mechanisms by antimicrobial peptides. J Invest Dermatol 2005; 125:9-13. ABSTRACT  |  PDF
Lawrence T, Bebien M, Liu GY, Nizet V, Karin M. IKKα limits macrophage NF-κB activation and contributes to the resolution of inflammation. Nature 2005 434:1138-43. ABSTRACT  |  PDF
Datta V, Myskowski SM, Kwinn LA, Chiem DN, Varki N, Kansal R, Kotb M, Nizet V. Mutational analysis of the group A streptococcal operon encoding streptolysin S and its virulence role in invasive infection. Mol Microbiol 2005; 56:681-95. ABSTRACT  |  PDF
Hensler ME, Liu GY, Sobczak S, Benirshcke K, Nizet V, Heldt GP. Virulence role of the group B streptococcal β-hemolysin/cytolysin in a neonatal rabbit model of early onset pulmonary infection. J Infect Dis 2005; 191:1287-91. ABSTRACT  |  PDF
Lauth X, Babon J, Stannard JA, Singh S, Nizet V, Carlberg JM, Ostland VE, Pennington MW, Norton RS, Westerman ME. Bass hepdicin: synthesis, solution structure, antimicrobial activities and synergism, and in vivo hepatic response to bacterial infections. J Biol Chem 2005; 280:9272-82. ABSTRACT  |  PDF
Liu GY, Doran KS, Lawrence T, Turkson N, Puliti M, Tissi L, Nizet V. Sword and shield: Linked group B streptococcal β-hemolysin/cytolysin and carotenoid pigment act synergistically to subvert phagocytic defenses. Proc Natl Acad Sci USA 2004; 101:14491-6. ABSTRACT  |  PDF
Doran KS, Nizet V. Molecular pathogenesis of neonatal group B streptococcal infection: No longer in its infancy. Mol Microbiol 2004; 54:23-31. ABSTRACT  |  PDF
Lewis A, Nizet V, Varki A. Discovery and characterization of sialic acid O-acetylation in group B Streptococcus. Proc Natl Acad Sci USA 2004; 101:11123-8. ABSTRACT  |  PDF
Bardan A, Nizet V, Gallo RL. Antimicrobial peptides and the skin. Expert Opin Biol Ther 2004; 4:543-9. ABSTRACT  |  PDF
Hidalgo-Grass C, Dan-Goor M, Maly A, Eran Y, Kwinn LA, Nizet V, Ravins M, Jaffe J, Moses AE, Hanski E. Effect of a bacterial pheromone peptide on host chemokines in group A streptococcal necrotising soft tissue infections. Lancet 2004; 263:696-703. ABSTRACT  |  PDF
Front-Biosci.png Liu GY, Nizet V. Extracellular virulence factors of group B Streptococcus. Front Biosci 2004; 9:1794-1802. ABSTRACT  |  PDF
Aziz RK, Pabst MJ, Jeng A, Kansal R, Low DE, Nizet V, Kotb M. Invasive M1T1 group A Streptococcus undergoes an in vivo phase-shift to prevent proteolytic degradation of multiple virulence factors by SpeB. Mol Microbiol 2004; 51:123-34. ABSTRACT  |  PDF
Doran KS, Liu GY, Nizet V. Group B streptococcal β-hemolysin/cytolysin activates neutrophil signaling pathways in brain endothelium and contributes to development of meningitis. J Clin Invest 2003; 112:736-44. ABSTRACT  |  PDF
Nizet V, Gallo RL. Cathelicidins and innate defense against invasive bacterial infection. Scand J Infect Dis 2003; 35:670-6. ABSTRACT  |  PDF
Ped-Emerg-Care.png Saitoh A, Beall B, Nizet V. Fulminant bacterial meningitis complicating sphenoid sinusitis. Ped Emerg Care 2003; 19:415-7. ABSTRACT  |  PDF
Gallo RL, Nizet V. Endogenous production of antimicrobial peptides in innate immunity and human disease. Curr Allergy Asthma Rep 2003; 3:402-9. ABSTRACT  |  PDF
Zaiou M, Nizet V, Gallo RL. Antimicrobial and protease inhibitory functions of the human cathelicidin (hCAP18/LL-37) prosequence. J Invest Dermatol 2003; 120:810-6. ABSTRACT  |  PDF
Kristian SA, Lauth X, Nizet V, Götz F, Neumeister B, Peschel A, Landmann R. Alanylation of teichoic acids protects Staphylococcus aureus against Toll-like receptor 2-dependent host defense in a mouse tissue cage model. J Infect Dis 2003; 188:414-23. ABSTRACT  |  PDF
Cramer T, Yamanishi Y, Clausen BE, Forster I, Pawlinski R, Mackman N, Haase VH, Jaenisch R, Corr M, Nizet V, Firestein G, Gerber H-P, Ferrara N, Johnson RS. HIF-1α is essential for myeloid cell-mediated inflammation. Cell 2003; 112:645-57. ABSTRACT  |  PDF
Kansal RG, Nizet V, Jeng A, Chaung WJ, Kotb M. Selective modulation of superantigen induced responses by streptococcal cysteine protease. J Infect Dis 2003; 187:398-407. ABSTRACT  |  PDF
Jeng A, Li Z, Sakota V, Datta V, Beall B, Nizet V. Molecular genetic analysis of a group A streptococcal operon encoding serum opacity factor and a novel fibronectin-binding protein, SfbX. J Bacteriol 2003; 185:1208-17. ABSTRACT  |  PDF
Nizet V. Streptococcal β-hemolysins: Genetics and role in disease pathogenesis. Trends Microbiol 2002; 10:575-580. ABSTRACT  |  PDF
Ring A, Depnering C, Pohl J, Nizet V, Shenep JL, Stremmel W. Synergistic action of nitric oxide release from murine macrophages caused by group B streptococcal cell wall and beta-hemolysin/cytolysin. J Infect Dis 2002; 186:1518-1521. ABSTRACT  |  PDF
JI.png Henneke P, Takeuchi O, Malley R, Lien E, Ingalls RR, Freeman MW, Mayadas-Norton T, Nizet V, Akira S, Kasper DL, Golenbock DT. Cellular activation, phagocytosis, and bactericidal activity against group B Streptococcus involve separate but parallel MyD88 dependent and MyD88 independent signaling pathways. J Immunol 2002; 169:3970-7. ABSTRACT  |  PDF
Fuller JD, Camus A, Duncan CL, Nizet V, Bast DJ, Thune RL, Low DE, De Azavedo JCS. Discovery of a streptolysin S-associated gene cluster and its role in the pathogenesis of Streptococcus iniae disease. Infect Immun 2002; 70:5730-9. ABSTRACT  |  PDF
Ring A, Braun JS, Pohl J, Nizet V, Stremmel W, Shenep JL. Group B streptococcal β-hemolysin induces mortality and liver injury in experimental sepsis. J Infect Dis 2002; 185:1745-53. ABSTRACT  |  PDF
Nizet V, Gallo RL. News & Comment: Surviving innate immunity. Trends Microbiol 2002; 10:358-9.  PDF
Doran KS, Benoit VM, Gertz RE, Jr., Beall B, Nizet V. Late-onset group B streptococcal infection in identical twins: insight to disease pathogenesis. J Perinatol 2002; 22:326-30. ABSTRACT  |  PDF
Lauth X, Shike H, Burns JC, Westerman ME, Ostland VE, Carlberg JM, Van Olst JC, Nizet V, Taylor SW, Jennings PA, Shimizu C, Bulet P. Discovery and characterization of two isoforms of moronecidin, a novel antimicrobial peptide from hybrid striped bass. J Biol Chem 2002; 277:5030-9. ABSTRACT  |  PDF
Doran KS, Chang JCW, Benoit VM, Eckmann L, Nizet V. Group B streptococcal β-hemolysin/cytolysin promotes invasion of human lung epithelial cells and the release of interleukin-8. J Infect Dis 2002; 185:196-203. ABSTRACT  |  PDF
lancet.png Humar D, Datta V, Bast DJ, Beall B, De Azavedo JCS, Nizet V. Streptolysin S and necrotizing soft tissue infections produced by group G Streptococcus. Lancet 2002; 359:124-9. ABSTRACT  |  PDF
Ballon-Landa G, Gherardi G, Beall B, Krosner S, Nizet V. Necrotizing fasciitis due to penicillin-resistant Streptococcus pneumoniae: Case report and review of the literature. J Infect 2001; 42:272-80. ABSTRACT  |  PDF
JI.png Henneke P, Takeuchi O, van Strijp JA, Guttormsen H-K, Smith JA, Schromm AB, Espevik TA, Akira S, Nizet V, Kasper D, Golenbock DT. Novel engagement of CD14 and multiple Toll-like receptors by group B streptococci. J Immunol 2001; 167:7069–76. ABSTRACT  |  PDF
Nizet V, Ohtake T, Lauth X, Trowbridge J, Rudisill J, Dorschner R, Pestonjamasp V, Piriano J, Huttner K, Gallo RL. Innate antimicrobial peptide protects the skin from invasive bacterial infection. Nature 2001; 414:454-7. ABSTRACT  |  PDF
Dorschner RA, Pestonjamasp V, Tamakuwala S, Ohtake T, Rudisill J, Nizet V, Agerberth B, Gudmundsson G, Gallo RL. Cutaneous injury induces release of cathelicidin antimicrobial peptides active against group A Streptococcus. J Invest Dermatol 2001; 117:91-7. ABSTRACT  |  PDF
Fuller JD, Bast DJ, Nizet V, Low DE, de Azavedo JCS. Streptococcus iniae virulence is associated with a distinct genetic profile. Infect Immun 2001; 69: 1994-2000. ABSTRACT  |  PDF
Pritzlaff CA, Chang JCW, Kuo SP, Tamura GS, Rubens CE, Nizet V. Genetic basis for the β-haemolytic/cytolytic activity of group B Streptococcus. Mol Microbiol 2001; 39: 236-47. ABSTRACT  |  PDF
Puliti M, Nizet V, von Hunolstein C, Bistoni F, Mosci P, Orefici G, Tissi L. Severity of group B streptococcal arthritis is correlated with β-hemolysin expression. J Infect Dis 2000; 182:824-32. ABSTRACT  |  PDF
Ring A, Braun J, Nizet V, Stremmel W, Shenep JL. Group B streptococcal β-hemolysin induces nitric oxide production in murine macrophages. J Infect Dis 2000; 182:150-7. ABSTRACT  |  PDF
Nizet V, Beall B, Bast DJ, Datta V, Kilburn L, Low DE, de Azavedo JCS. Genetic locus for streptolysin S production by group A Streptococcus. Infect Immun 2000; 68:4245-54. ABSTRACT  |  PDF
Charland N, Nizet V, Rubens CE, Kim KS, Lacouture S, Nanci A, Gottschalk M. Streptococcus suis serotype 2 interactions with brain microvascular endothelial cells. Infect Immun 2000; 68:637-43. ABSTRACT  |  PDF
Gibson RL, Nizet V, Rubens CE. Group B streptococcal β-hemolysin promotes injury of lung microvascular endothelial cells. Pediatr Res 1999; 45:626-34. ABSTRACT  |  PDF
Nizet V, Smith AL, Sullam PM, Rubens CE. A simple microtiter plate screening assay for bacterial invasion or adherence. Methods Cell Sci 1998; 20:107-11. ABSTRACT  |  PDF
Nizet V, Kim KS, Stins M, Jonas M, Chi EY, Nguyen D, Rubens CE. Invasion of brain microvascular endothelial cells by group B streptococci. Infect Immun 1997; 65:5074-81. ABSTRACT  |  PDF
La Penta D; Framson P; Nizet V; Rubens CE. Epithelial cell invasion by group B streptococci is important to virulence. Adv Exp Med Biol 1997; 418:631-4. ABSTRACT  
Nizet V; Gibson RL; Rubens CE. The role of group B streptococci beta-hemolysin expression in newborn lung injury. Adv Exp Med Biol, 1997; 418:627-30. ABSTRACT  
New-Eng-J-Med.png Brogan TV, Nizet V, Waldhausen JHT. Correspondence: Streptococcal skin infections. New Engl J Med 1996; 334:1478. ABSTRACT  |  PDF
Nizet V, Gibson RL, Chi EY, Framson PE, Hulse M, Rubens CE. Group B streptococcal beta-hemolysin expression is associated with injury of lung epithelial cells. Infect Immun 1996; 64:3818-26. ABSTRACT  |  PDF
Nizet V, Colina KF, Almquist JR, Rubens CE, Smith AL. A virulent nonencapsulated Haemophilus influenzae. J Infect Dis 1996; 173:180-6. ABSTRACT  |  PDF
J-Ped-Ortho.png Mills WJ, Mosca VS, Nizet V. Orthopaedic manifestations of invasive group A streptococcal infections complicating primary varicella. J Ped Ortho 1996; 16:522-8. ABSTRACT  |  PDF
Nizet V, Brogan TV. Enterococcal necrotizing fasciitis complicating elective hernia repair in an infant. Infect Dis Clin Pract 1996; 5:76-8 ABSTRACT  |  PDF
Brogan TV, Nizet V, Waldhausen JHT, Rubens CE, Clarke WR. Group A streptococcal necrotizing fasciitis complicating primary varicella: a series of fourteen patients. Ped Infect Dis J 1995; 14:588-94. ABSTRACT  |  PDF